About: Evaluation of electrospray differential mobility analysis for virus particle analysis: Potential applications for biomanufacturing

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About: Evaluation of electrospray differential mobility analysis for virus particle analysis: Potential applications for biomanufacturing Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of electrospray differential mobility analysis for virus particle analysis: Potential applications for biomanufacturing
Creator	Guha, Suvajyoti Brorson, Kurt Pease Iii, Leonard Tarlov, Michael Zachariah, Michael
Source	Elsevier; Medline; PMC
abstract	The technique of electrospray differential mobility analysis (ES-DMA) was examined as a potential potency assay for routine virus particle analysis in biomanufacturing environments (e.g., evaluation of vaccines and gene delivery products for lot release) in the context of the International Committee of Harmonisation (ICH) Q2 guidelines. ES-DMA is a rapid particle sizing method capable of characterizing certain aspects of the structure (such as capsid proteins) and obtaining complete size distributions of viruses and virus-like particles. It was shown that ES-DMA can distinguish intact virus particles from degraded particles and measure the concentration of virus particles when calibrated with nanoparticles of known concentration. The technique has a measurement uncertainty of ≈20%, is linear over nearly 3 orders of magnitude, and has a lower limit of detection of ≈10(9) particles/mL. This quantitative assay was demonstrated for non-enveloped viruses. It is expected that ES-DMA will be a useful method for applications involving production and quality control of vaccines and gene therapy vectors for human use.
has issue date	2011-09-21(xsd:dateTime)
bibo:doi	10.1016/j.jviromet.2011.09.012
bibo:pmid	21963394
has license	no-cc
sha1sum (hex)	20a514f4c66e47b35d2fed043146ac22ad71dbaa
schema:url	https://doi.org/10.1016/j.jviromet.2011.09.012
resource representing a document's title	Evaluation of electrospray differential mobility analysis for virus particle analysis: Potential applications for biomanufacturing
has PubMed Central identifier	PMC7112809
has PubMed identifier	21963394
schema:publication	J Virol Methods
resource representing a document's body	covid:20a514f4c66e47b35d2fed043146ac22ad71dbaa#body_text
is schema:about of	named entity 'gene therapy' named entity 'orders' named entity 'vaccines' named entity 'particles' named entity 'release' named entity 'The technique' named entity 'potency' named entity 'non-enveloped' named entity 'particles' named entity 'mobility' named entity 'DMA' named entity 'MAGNITUDE' named entity 'GENE THERAPY VECTORS' named entity 'CONCENTRATION' named entity 'STRUCTURE' named entity 'COMPLETE' named entity 'DISTRIBUTIONS' named entity 'HUMAN USE' named entity 'RAPID' named entity 'COMMITTEE' named entity 'LOWER LIMIT OF DETECTION' named entity 'INTACT' named entity 'NEARLY' named entity 'EXAMINED' covid:arg/20a514f4c66e47b35d2fed043146ac22ad71dbaa named entity 'SIZE' named entity 'DIFFERENTIAL' named entity 'APPLICATIONS' named entity 'EXPECTED' named entity 'VACCINES' named entity 'RELEASE' named entity 'CAPABLE' named entity 'ANALYSIS' named entity 'EVALUATION' named entity 'VIRUS PARTICLE' named entity 'POTENTIAL' named entity 'MOBILITY' named entity 'NON-' named entity 'PARTICLE SIZING' named entity 'PARTICLES' named entity 'ANALYSIS' named entity 'VIRUSES' named entity 'MOBILITY' named entity 'CONTEXT' named entity 'ENVIRONMENTS' named entity 'INVOLVING' named entity 'VIRUS-LIKE PARTICLES' named entity 'ORDERS' named entity 'DIFFERENTIAL' named entity 'CALIBRATED' named entity 'NANOPARTICLES' named entity 'QUALITY CONTROL' named entity 'GUIDELINES' named entity 'QUANTITATIVE' named entity 'MEASURE' named entity 'TECHNIQUE' named entity 'ASSAY' named entity 'DEGRADED' named entity 'POTENTIAL' named entity 'UNCERTAINTY' named entity 'CONCENTRATION OF' named entity 'METHOD' named entity 'IS A' named entity 'USEFUL' named entity 'MEASUREMENT' named entity 'APPLICATIONS' named entity 'DEMONSTRATED' named entity 'VIRUS PARTICLE' named entity 'CAPSID PROTEINS' named entity 'GENE DELIVERY' named entity 'LOT' named entity 'PRODUCTS' named entity 'INTERNATIONAL' named entity 'KNOWN' named entity 'LINEAR' named entity 'EVALUATION' named entity 'ROUTINE'

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