About: Cloning, expression and characterization of ferret CXCL10

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cloning, expression and characterization of ferret CXCL10
Creator	Banner, David Danesh, Ali Xu, Luoling Ran, Longsi Rowe, Thomas Cameron, Cheryl Kelvin, David Czub, Marcus Seneviratne, Charit Cameron, Mark Jonsson, Colleen Bosinger, Steven Devries, Mark Kelvin, Alyson
Source	Elsevier; Medline; PMC
abstract	Chemokines and their receptors function in the recruitment and activation of cells of the immune system to sites of inflammation. As such, chemokines play an important role in mediating pathophysiological events during microbial infection. In particular, CXCL9, 10 and 11 and their cognate receptor CXCR3 have been associated with the clinical course of several infectious diseases, including severe acute respiratory syndrome (SARS) and influenza. While CXCL9, 10 and 11 share the same receptor and have overlapping functions, each can also have unique activity in host defense. The lack of a preferred characterized animal model for SARS has brought our attention to ferrets, which have been used for years in influenza studies. The lack of immunological reagents for ferrets prompted us to clone CXCL9, 10, 11 and CXCR3 and, in the case of CXCL10, to express the gene as a recombinant protein. In this study we demonstrate that endogenous ferret CXCL10 exhibits similar mRNA expression patterns in the lungs of deceased SARS patients and ferrets experimentally infected with SARS coronavirus. This study therefore represents an important step towards development of the ferret as a model for the role of CXCL9, 10 and 11:CXCR3 axis in severe viral infections.
has issue date	2008-03-01(xsd:dateTime)
bibo:doi	10.1016/j.molimm.2007.09.018
bibo:pmid	18006061
has license	green-oa
sha1sum (hex)	20a38a054a302914d42eb2b228afb705702de803
schema:url	https://doi.org/10.1016/j.molimm.2007.09.018
resource representing a document's title	Cloning, expression and characterization of ferret CXCL10
has PubMed Central identifier	PMC5653245
has PubMed identifier	18006061
schema:publication	Molecular Immunology
resource representing a document's body	covid:20a38a054a302914d42eb2b228afb705702de803#body_text
is schema:about of	named entity 'preferred' named entity 'immune system' named entity 'REAGENTS' named entity 'ASSOCIATED WITH' named entity 'MRNA EXPRESSION' named entity 'INCLUDING' named entity 'LACK' named entity 'STUDIES' named entity 'CLONE' named entity 'STUDY' named entity 'MICROBIAL INFECTION' named entity 'INFLAMMATION' named entity 'MODEL' named entity 'PATTERNS' named entity 'INFECTIOUS DISEASES' named entity 'FERRET' named entity 'ACTIVITY' named entity 'RECEPTOR' named entity 'CHEMOKINES' named entity 'ACTIVATION' named entity 'DECEASED' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'USED' named entity 'RECRUITMENT' named entity 'CXCR3' named entity 'THEIR' named entity 'OVERLAPPING' named entity 'TO EXPRESS' named entity 'CHARACTERIZATION' named entity 'CXCL10' named entity 'CLONING' named entity 'FERRET' named entity 'EXPRESSION' named entity 'ATTENTION' named entity 'CXCL10' named entity 'SEVERE VIRAL INFECTIONS' named entity 'ANIMAL MODEL' named entity 'FUNCTION' named entity 'MEDIATING' named entity 'IMMUNE SYSTEM' named entity 'SHARE' named entity 'INFLUENZA' named entity 'PARTICULAR' named entity 'GENE' named entity 'RECEPTORS' named entity 'HAVE' named entity 'CASE' named entity 'FERRETS' named entity 'HOST DEFENSE' named entity 'EXHIBITS' named entity 'OUR' named entity 'SITES' named entity 'ROLE' named entity 'PREFERRED' named entity 'IMPORTANT' named entity 'RECOMBINANT PROTEIN' named entity 'ENDOGENOUS' named entity 'BROUGHT' named entity 'SARS CORONAVIRUS' named entity 'SARS' named entity 'FUNCTIONS' named entity 'THE LUNGS' named entity 'INFECTED' named entity 'YEARS' named entity 'PATIENTS' named entity 'PLAY' named entity 'PROMPTED' named entity 'CELLS'

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