About: SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus

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About: SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus
Creator	Kohara, Michinori Matsushima, Kouji Mizuno, Kyosuke Yasui, Fumihiko Arai, Masaaki Inoue, Shingo Kidokoro, Minoru Kitabatake, Masahiro Morita, Kouichi Murai, Fukashi Shida, Hisatoshi Yokochi, Shoji Le, Mai
source	Elsevier; Medline; PMC
abstract	Abstract A vaccine for severe acute respiratory syndrome (SARS) is being intensively pursued against its re-emergence. We generated a SARS coronavirus (SARS-CoV) spike protein-expressing recombinant vaccinia virus (RVV-S) using highly attenuated strain LC16m8. Intradermal administration of RVV-S into rabbits induced neutralizing (NT) antibodies against SARS-CoV 1 week after administration and the NT titer reached 1:1000 after boost immunization with RVV-S. Significantly, NT antibodies against SARS-CoV were induced by administration of RVV-S to rabbits that had been pre-immunized with LC16m8. RVV-S can induce NT antibodies against SARS-CoV despite the presence of NT antibodies against VV. These results suggest that RVV-S may be a powerful SARS vaccine, including in patients previously immunized with the smallpox vaccine.
has issue date	2007-01-08(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2006.08.039
bibo:pmid	17011679
has license	els-covid
sha1sum (hex)	1fe6777710bd340802122284b0c016a9c1c281fa
schema:url	https://doi.org/10.1016/j.vaccine.2006.08.039
resource representing a document's title	SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus
has PubMed Central identifier	PMC7115632
has PubMed identifier	17011679
schema:publication	Vaccine
resource representing a document's body	covid:1fe6777710bd340802122284b0c016a9c1c281fa#body_text
is schema:about of	named entity 'VACCINIA VIRUS' named entity 'SARS-CoV' named entity 'presence' named entity 'administration' named entity 'antibodies' named entity 'antibodies' named entity 'titer' named entity 'recombinant' named entity 'vaccinia virus' named entity 'induces' named entity 'RECOMBINANT VACCINIA VIRUS' named entity 'STRAIN' named entity 'SPIKE PROTEIN' named entity 'GENERATED' named entity 'ANTIBODIES' named entity 'ITS' named entity 'BOOST' named entity 'PATIENTS' named entity 'HIGHLY' named entity 'VACCINE' named entity 'SPIKE PROTEIN' named entity 'RABBITS' named entity 'BEING' named entity 'INDUCED' named entity 'SARS-COV' named entity 'IMMUNIZED' named entity 'NEUTRALIZING ANTIBODIES' named entity 'PRE' named entity 'THESE' named entity 'PRE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'SARS VACCINE' named entity 'RECOMBINANT VACCINIA VIRUS' named entity 'POWERFUL' named entity 'IMMUNIZATION' named entity 'ADMINISTRATION' named entity 'ATTENUATED' named entity 'EMERGENCE' named entity 'PRESENCE OF' named entity 'INCLUDING' named entity 'PREVIOUSLY' named entity 'IMMUNIZED' named entity 'TITER' named entity 'SMALLPOX VACCINE' named entity 'MAY BE A' named entity 'RESULTS' named entity 'USING' named entity 'SUGGEST' named entity 'LC16M8' named entity 'SARS CORONAVIRUS' named entity 'INTRADERMAL ADMINISTRATION' named entity 'RABBITS' named entity 'INDUCE' named entity '1 WEEK' covid:arg/1fe6777710bd340802122284b0c016a9c1c281fa named entity 'induced' named entity 'SARS-CoV' named entity 'rabbits' named entity 'antibodies' named entity 'spike' named entity 'induced' named entity 'attenuated' named entity 'induce' named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'spike protein' named entity 'smallpox vaccine' named entity 'recombinant' named entity 'spike protein'

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