About: Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure

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About: Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure
Creator	Halappanavar, Sabina Kuo, Byron Moffat, Ivy Vogel, Ulla Wallin, Håkan Williams, Andrew White, Paul Yauk, Carole Bourdon, Julie
topic	covid:1fe201bcf1ed66856f693846cb0d07ce48051ec1#this
Source	Elsevier; Medline; PMC
abstract	Abstract New approaches are urgently needed to evaluate potential hazards posed by exposure to nanomaterials. Gene expression profiling provides information on potential modes of action and human relevance, and tools have recently become available for pathway-based quantitative risk assessment. The objective of this study was to use toxicogenomics in the context of human health risk assessment. We explore the utility of toxicogenomics in risk assessment, using published gene expression data from C57BL/6 mice exposed to 18, 54 and 162μg Printex 90 carbon black nanoparticles (CBNP). Analysis of CBNP-perturbed pathways, networks and transcription factors revealed concomitant changes in predicted phenotypes (e.g., pulmonary inflammation and genotoxicity), that correlated with dose and time. Benchmark doses (BMDs) for apical endpoints were comparable to minimum BMDs for relevant pathway-specific expression changes. Comparison to inflammatory lung disease models (i.e., allergic airway inflammation, bacterial infection and tissue injury and fibrosis) and human disease profiles revealed that induced gene expression changes in Printex 90 exposed mice were similar to those typical for pulmonary injury and fibrosis. Very similar fibrotic pathways were perturbed in CBNP-exposed mice and human fibrosis disease models. Our synthesis demonstrates how toxicogenomic profiles may be used in human health risk assessment of nanoparticles and constitutes an important step forward in the ultimate recognition of toxicogenomic endpoints in human health risk. As our knowledge of molecular pathways, dose–response characteristics and relevance to human disease continues to grow, we anticipate that toxicogenomics will become increasingly useful in assessing chemical toxicities and in human health risk assessment.
has issue date	2013-01-07(xsd:dateTime)
bibo:doi	10.1016/j.tox.2012.10.014
bibo:pmid	23146762
has license	els-covid
sha1sum (hex)	1fe201bcf1ed66856f693846cb0d07ce48051ec1
schema:url	https://doi.org/10.1016/j.tox.2012.10.014
resource representing a document's title	Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure
has PubMed Central identifier	PMC7125805
has PubMed identifier	23146762
schema:publication	Toxicology
resource representing a document's body	covid:1fe201bcf1ed66856f693846cb0d07ce48051ec1#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/1fe201bcf1ed66856f693846cb0d07ce48051ec1
is schema:about of	named entity 'HUMAN HEALTH RISK ASSESSMENT' named entity 'revealed' named entity 'BMDs' named entity 'allergic' named entity 'human' named entity 'correlated' named entity 'Gene expression profiling' named entity 'ANALYSIS' named entity 'QUANTITATIVE' named entity 'BENCHMARK' named entity 'EVALUATE' named entity 'INFLAMMATORY LUNG DISEASE' named entity 'INDUCED' named entity 'CHANGES' named entity 'HUMAN' named entity 'DOSES' named entity 'HUMAN HEALTH RISK' named entity 'MINIMUM' named entity 'NETWORKS' named entity 'TOOLS' named entity 'UTILITY' named entity '162' named entity 'AVAILABLE' named entity 'STEP' named entity 'FIBROSIS' named entity 'GROW' named entity 'ENDPOINTS' named entity 'KNOWLEDGE' named entity 'HAZARDS' named entity 'EXPOSURE TO' covid:arg/1fe201bcf1ed66856f693846cb0d07ce48051ec1 named entity 'REVEALED' named entity 'ASSESSING' named entity 'DISEASE MODELS' named entity '28I' named entity 'TIME' named entity 'RECENTLY' named entity 'PATHWAYS' named entity 'GENE EXPRESSION PROFILING' named entity 'USEFUL' named entity 'APPROACHES' named entity 'RELEVANT' named entity 'OUTCOMES' named entity 'SUPPORT' named entity 'GENE EXPRESSION PROFILING' named entity 'EXPOSURE' named entity 'TOXICOLOGY' named entity 'DISEASE' named entity 'TO IDENTIFY' named entity 'CARBON BLACK NANOPARTICLE' named entity 'PROVIDES' named entity 'IMPORTANT' named entity 'PULMONARY INJURY' named entity 'SPECIFIC' named entity 'FIBROTIC' named entity 'HOW' named entity 'RISK ASSESSMENT' named entity 'EXPOSED' named entity 'OUR' named entity 'NANOPARTICLES' named entity 'DOSE' named entity 'PATHWAY' named entity 'NEW' named entity 'USED' named entity 'USING' named entity 'GENE EXPRESSION DATA' named entity 'RELEVANCE' named entity 'PHENOTYPES' named entity 'MOLECULAR PATHWAYS' named entity 'COMPARISON' named entity 'APICAL'

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