About: Distinct Viral Clades of SARS‐CoV‐2: Implications for Modeling of Viral Spread

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Distinct Viral Clades of SARS‐CoV‐2: Implications for Modeling of Viral Spread
Creator	Brufsky, Adam
Source	Medline; PMC
abstract	Distinct viral clades have a likely impact on COVID‐19 pathogenesis and spread. Sequence analysis from 2310 viral isolates from Nexstrain reveals that residue at 614 of the viral spike protein is changed from a putative ancestral aspartic acid (D) to a glycine (G) between two viral clades. The G strain is predominantly on the East Coast of the United States, and the D strain is predominantly on the West Coast. This mutation of the SARS‐CoV‐2 S protein spike is conserved in coronaviruses. Point mutations in a murine coronavirus spike protein can result in increased virulence through instability of the viral machinery and altered viral to cell membrane fusion. This observation may partially explain the discrepancy in predicted deaths from COVID‐19 between the East Coast and West Coast, and possibly explain that other factors aside from social distance, such as competition between two strains of differing virulence, may be at play. This article is protected by copyright. All rights reserved.
has issue date	2020-04-20(xsd:dateTime)
bibo:doi	10.1002/jmv.25902
bibo:pmid	32311094
has license	no-cc
sha1sum (hex)	1eba3880e79e9b14caa628d5fc98859d16db4afc
schema:url	https://doi.org/10.1002/jmv.25902
resource representing a document's title	Distinct Viral Clades of SARS‐CoV‐2: Implications for Modeling of Viral Spread
has PubMed Central identifier	PMC7264516
has PubMed identifier	32311094
schema:publication	J Med Virol
resource representing a document's body	covid:1eba3880e79e9b14caa628d5fc98859d16db4afc#body_text
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