About: Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT
Creator	Tan, Yee-Joo Chou, Chih-Fong Hong, Wanjin Shen, Shuo Gunalan, Vithiagaran Khan, Sehaam Fielding, Burtram Lim, Seng Tan, Timothy
Source	Elsevier; Medline; PMC
abstract	Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV) 7a is an accessory protein with no known homologues. In this study, we report the interaction of a SARS-CoV 7a and small glutamine-rich tetratricopeptide repeat-containing protein (SGT). SARS-CoV 7a and human SGT interaction was identified using a two-hybrid system screen and confirmed with interaction screens in cell culture and cellular co-localization studies. The SGT domain of interaction was mapped by deletion mutant analysis and results indicated that tetratricopeptide repeat 2 (aa 125-158) was essential for interaction. We also showed that 7a interacted with SARS-CoV structural proteins M (membrane) and E (envelope), which have been shown to be essential for virus-like particle formation. Taken together, our results coupled with data from studies of the interaction between SGT and HIV-1 vpu indicated that SGT could be involved in the life-cycle, possibly assembly of SARS-CoV.
has issue date	2006-05-19(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2006.03.091
bibo:pmid	16580632
has license	els-covid
sha1sum (hex)	1e23bde4e435cbcb5f23f6b1dc2f6687f1c3b221
schema:url	https://doi.org/10.1016/j.bbrc.2006.03.091
resource representing a document's title	Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT
has PubMed Central identifier	PMC7092935
has PubMed identifier	16580632
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:1e23bde4e435cbcb5f23f6b1dc2f6687f1c3b221#body_text
is schema:about of	named entity 'MUTANT' named entity 'HUMAN' named entity 'CONTAINING' named entity 'GLUTAMINE' named entity 'SGT' named entity 'SCREEN' named entity 'DOMAIN' named entity 'REPORT' named entity 'INTERACTION' named entity 'RESULTS' named entity 'TETRATRICOPEPTIDE REPEAT' named entity 'RICH' named entity 'mutant' named entity 'HAVE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'STUDY' named entity 'HIV-1' named entity '158' named entity 'COULD BE' named entity 'VPU' named entity 'ASSEMBLY' named entity 'IDENTIFIED' named entity 'ESSENTIAL' named entity 'OUR' named entity 'STUDIES' named entity 'INVOLVED' named entity 'MAPPED' named entity 'ANALYSIS' named entity 'COUPLED' named entity 'STRUCTURAL PROTEINS' named entity 'SYSTEM' named entity '125' named entity 'PROTEIN ' named entity 'HSGT' named entity 'SMALL' named entity 'ACCESSORY PROTEIN' named entity 'VIRUS-LIKE PARTICLE' named entity 'SARS-COV' named entity 'TWO-HYBRID' named entity 'PROTEIN ' named entity 'CONFIRMED' named entity 'LIFE-CYCLE' named entity 'DELETION' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'INDICATED' named entity 'DATA' named entity 'TAKEN' named entity 'CELL CULTURE' named entity 'KNOWN' named entity 'CO-LOCALIZATION' named entity 'POSSIBLY' named entity 'CELLULAR' named entity 'PARTICLE FORMATION' named entity 'USING' named entity 'SGT' named entity 'SARS-CoV' named entity 'studies' named entity 'SARS-CoV' named entity 'cell culture' named entity 'homologues' named entity 'nucleocapsid' named entity 'Clontech' named entity 'immunoprecipitated' named entity 'nucleotide sequence' named entity 'Vero E6 cells' named entity 'phenotypes' named entity 'ORF' named entity 'nucleocapsid' named entity 'Mammalian cell' named entity 'HIV-1' named entity 'AH109' named entity 'Vero E6' named entity 'sequence identity'

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