About: Protective role of neuronal and lymphoid cannabinoid CB(2) receptors in neuropathic pain

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About: Protective role of neuronal and lymphoid cannabinoid CB(2) receptors in neuropathic pain Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protective role of neuronal and lymphoid cannabinoid CB(2) receptors in neuropathic pain
Creator	Drews, Eva Ferrer-Montiel, Antonio Kummer, Sami Maldonado, Rafael Otte, David Przewlocki, Ryszard Wawrzczak-Bargiela, Agnieszka Zimmer, Andreas Cabañ Ero, David Encabo, Hector Ramírez-Ló Pez, Angela Schmö Le, Anne
Source	PMC
abstract	Cannabinoid CB(2) receptor (CB(2)) agonists are potential analgesics void of psychotropic effects. Peripheral immune cells, neurons and glia express CB(2); however, the involvement of CB(2) from these cells in neuropathic pain remains unresolved. We explored spontaneous neuropathic pain through on-demand self-administration of the selective CB(2) agonist JWH133 in wild-type and knockout mice lacking CB(2) in neurons, monocytes or constitutively. Operant self-administration reflected drug-taking to alleviate spontaneous pain, nociceptive and affective manifestations. While constitutive deletion of CB(2) disrupted JWH133-taking behavior, this behavior was not modified in monocyte-specific CB(2) knockouts and was increased in mice defective in neuronal CB(2) knockouts suggestive of increased spontaneous pain. Interestingly, CB(2)-positive lymphocytes infiltrated the injured nerve and possible CB(2)transfer from immune cells to neurons was found. Lymphocyte CB(2)depletion also exacerbated JWH133 self-administration and inhibited antinociception. This work identifies a simultaneous activity of neuronal and lymphoid CB(2)that protects against spontaneous and evoked neuropathic pain.
has issue date	2020-07-20(xsd:dateTime)
bibo:doi	10.7554/elife.55582
bibo:pmid	32687056
has license	cc-by
sha1sum (hex)	1d6d2755693016c16d5555a7687cfed38c659415
schema:url	https://doi.org/10.7554/elife.55582
resource representing a document's title	Protective role of neuronal and lymphoid cannabinoid CB(2) receptors in neuropathic pain
has PubMed Central identifier	PMC7384863
has PubMed identifier	32687056
resource representing a document's body	covid:1d6d2755693016c16d5555a7687cfed38c659415#body_text
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