About: The p7 protein of the hepatitis C virus induces cell death differently from the influenza A virus viroporin M2

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About: The p7 protein of the hepatitis C virus induces cell death differently from the influenza A virus viroporin M2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The p7 protein of the hepatitis C virus induces cell death differently from the influenza A virus viroporin M2
Creator	Tan, Yee-Joo Juventus Aweya, Jude Lim, Seng Mak, Minn
Source	Elsevier; Medline; PMC
abstract	Abstract Most viruses encode proteins that modulate cell-death signaling by the host. For hepatitis C virus (HCV) infection, apoptosis and other forms of cell-death have been observed in vitro and in vivo but the detailed understanding of this intricate viral-host interplay is unclear. This study examined the role played by the HCV p7 protein in the induction of cell-death. By measuring caspase-3/7 activation and cleavage of endogenous PARP, two hallmarks of apoptosis, the overexpression of p7 protein was shown to induce apoptosis in Huh7.5 cells. Furthermore, p7-induced apoptosis is caspase-dependent and involves both the intrinsic and extrinsic pathways. Similar to the M2 protein of influenza A virus, p7-induced apoptosis is independent of its ion channel activity. Coimmunoprecipitation experiments further showed that both M2 and p7 interact with the essential autophagy protein Beclin-1. However, only the M2 protein could cause an increase in the level of LC3-II, which is an indicator of autophagic activity. Thus, although the p7 protein is functionally similar to the well-characterized M2 protein, they differ in their activation of autophagic cell-death. Taken together, these results shed more light on the relationship between the HCV p7 ion channel protein and cell-death induction in host cells.
has issue date	2013-03-31(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2012.12.005
bibo:pmid	23246447
has license	els-covid
sha1sum (hex)	1d319d99c47121e61e0a0b91a600b29020aafbd4
schema:url	https://doi.org/10.1016/j.virusres.2012.12.005
resource representing a document's title	The p7 protein of the hepatitis C virus induces cell death differently from the influenza A virus viroporin M2
has PubMed Central identifier	PMC7114515
has PubMed identifier	23246447
schema:publication	Virus Research
resource representing a document's body	covid:1d319d99c47121e61e0a0b91a600b29020aafbd4#body_text
is schema:about of	named entity 'ITS' named entity 'AUTOPHAGY' named entity 'CASPASE-3' named entity 'LEVEL' named entity '2F7' named entity 'EXTRINSIC' named entity 'HUH7' named entity 'RELATIONSHIP' named entity 'APOPTOSIS' named entity 'INDICATOR' named entity 'ENCODE' named entity 'EXAMINED' named entity 'BUT' named entity 'STUDY' named entity 'HCV' named entity 'proteins' named entity 'protein' named entity 'apoptosis' named entity 'activation' named entity 'p7 protein' covid:arg/1d319d99c47121e61e0a0b91a600b29020aafbd4 named entity 'ION CHANNEL PROTEIN' named entity 'IN VIVO' named entity 'HOST CELLS' named entity 'MODULATE' named entity 'BECLIN-1' named entity 'HAVE' named entity 'EXPERIMENTS' named entity 'OBSERVED' named entity 'LC3-II' named entity 'INTRINSIC' named entity 'INTERACT' named entity 'HEPATITIS C VIRUS' named entity 'PLAYED' named entity 'ROLE' named entity 'THESE' named entity 'HOST' named entity 'CELL' named entity 'VIRUSES' named entity 'DETAILED' named entity 'DEATH' named entity 'PATHWAYS' named entity 'COIMMUNOPRECIPITATION' named entity 'PROTEIN ' named entity 'HEPATITIS C VIRUS' named entity 'VIROPORIN' named entity 'CELL DEATH' named entity 'DEPENDENT' named entity 'ACTIVITY' named entity 'SIMILAR' named entity 'PROTEINS' named entity 'HCV' named entity 'OVEREXPRESSION' named entity 'SIGNALING' named entity 'INDEPENDENT OF' named entity 'CLEAVAGE' named entity 'INFECTION' named entity 'INDUCE' named entity 'INCREASE' named entity 'INDUCTION' named entity 'INDUCED' named entity 'INFLUENZA A VIRUS' named entity 'ION CHANNEL ACTIVITY' named entity 'CASPASE' named entity 'UNDERSTANDING' named entity 'LIGHT' named entity 'PROTEIN ' named entity 'FORMS' named entity 'ESSENTIAL' named entity 'THEIR' named entity 'PARP' named entity 'UNCLEAR' named entity 'CHARACTERIZED' named entity 'CELLS' named entity 'INFLUENZA A VIRUS' named entity 'RESULTS' named entity 'ENDOGENOUS' named entity 'IN VITRO'

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