About: The influence of time to adrenaline administration in the Paramedic 2 randomised controlled trial

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The influence of time to adrenaline administration in the Paramedic 2 randomised controlled trial
Creator	Quinn, Tom Finn, Judith Deakin, Charles Nolan, Jerry Perkins, Gavin Fothergill, Rachael Gates, Simon Gunson, Imogen Ji, Chen Kenna, Claire Lall, Ranjit O'shea, Lyndsey Pocock, Helen Rees, Nigel Scomparin, Charlotte
Source	PMC
abstract	PURPOSE: To examine the time to drug administration in patients with a witnessed cardiac arrest enrolled in the Pre-Hospital Assessment of the Role of Adrenaline: Measuring the Effectiveness of Drug Administration in Cardiac Arrest (PARAMEDIC2) randomised controlled trial. METHODS: The PARAMEDIC2 trial was undertaken across 5 NHS ambulance services in England and Wales with randomisation between December 2014 and October 2017. Patients with an out-of-hospital cardiac arrest who were unresponsive to initial resuscitation attempts were randomly assigned to 1 mg intravenous adrenaline or matching placebo according to treatment packs that were identical apart from treatment number. Participants and study staff were masked to treatment allocation. RESULTS: 8016 patients were enrolled, 4902 sustained a witnessed cardiac arrest of whom 2437 received placebo and 2465 received adrenaline. The odds of return of spontaneous circulation decreased in both groups over time but at a greater rate in the placebo arm odds ratio (OR) 0.93 (95% CI 0.92–0.95) compared with the adrenaline arm OR 0.96 (95% CI 0.95–0.97); interaction OR: 1.03, 95% CI 1.01–1.05, p = 0.005. By contrast, although the rate of survival and favourable neurological outcome decreased as time to treatment increased, the rates did not differ between the adrenaline and placebo groups. CONCLUSION: The rate of return of spontaneous circulation, survival and favourable neurological outcomes decrease over time. As time to drug treatment increases, adrenaline increases the chances of return of spontaneous circulation. Longer term outcomes were not affected by the time to adrenaline administration. (ISRCTN73485024). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-019-05836-2) contains supplementary material, which is available to authorized users.
has issue date	2020-01-07(xsd:dateTime)
bibo:doi	10.1007/s00134-019-05836-2
bibo:pmid	31912202
has license	cc-by-nc
sha1sum (hex)	1cb75c7daae9a73549f3cf21011d04b4846694b8
schema:url	https://doi.org/10.1007/s00134-019-05836-2
resource representing a document's title	The influence of time to adrenaline administration in the Paramedic 2 randomised controlled trial
has PubMed Central identifier	PMC7067734
has PubMed identifier	31912202
schema:publication	Intensive Care Med
resource representing a document's body	covid:1cb75c7daae9a73549f3cf21011d04b4846694b8#body_text
is schema:about of	named entity 'administration' named entity 'Role' named entity 'Effectiveness' named entity 'Administration' named entity 'Cardiac Arrest' named entity 'Adrenaline' named entity 'Pre-Hospital' named entity 'Paramedic' named entity 'covariate' named entity 'risk difference' named entity 'cardiac arrest' named entity 'placebo' named entity 'short duration' named entity 'defibrillation' named entity 'data monitoring committees' named entity 'risk difference' named entity 'treatment allocation' named entity 'placebo' named entity 'odds ratio' named entity 'AIC' named entity 'inter-quartile range' named entity 'treatment effects' named entity 'drug administration' named entity 'CPR' named entity 'linear models' named entity 'asphyxial' named entity 'paramedic' named entity 'OHCA' named entity 'cardiac arrest' named entity 'ascertainment bias' named entity 'CPR' named entity 'ROSC' named entity 'change over time' named entity 'mitochondrial' named entity '95% CI' named entity 'ROSC' named entity 'ROSC' named entity 'pulseless' named entity 'placebo' named entity 'Resuscitation' named entity 'resuscitation' named entity 'drug administration' named entity 'ambulance services' named entity 'drug administration' named entity 'hospital discharge' named entity 'ROSC' named entity '0.01' named entity 'epinephrine' named entity 'drug administration' named entity '95% CI' named entity 'modified Rankin scale' named entity 'ROSC' named entity 'ROSC' named entity 'cardiac arrest' named entity 'treatment effect' named entity 'drug treatment' named entity '95% CI' named entity 'shockable rhythm' named entity 'cardiopulmonary arrest' named entity 'double blind' named entity 'data collection' named entity '12.8' named entity 'treatment effects' named entity 'placebo' named entity 'cardiac arrest' named entity 'ROSC' named entity 'Sensitivity analysis'

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