About: Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice
Creator	Yang, Peng Zhao, Yan Li, Bo Sun, Yang Kuba, Keiji Jiang, Chengyu Guo, Feng Li, Qihan Wang, Chen Zhong, Nanshan Li, Dangsheng Liu, Kangtai Zou, Zhen Liu, Haolin Wang, Hongliang Gao, Jinming Han, Zongsheng Li, Chenggang Mo, Ziyao Song, Bin Wang, Chenxuan Penninger, Josef
Source	Medline; PMC
abstract	BACKGROUND: Nanoparticles have become a key technology in multiple industries. However, there are growing reports of the toxicity of nanomaterials to humans. In particular, nanomaterials have been linked to lung diseases. The molecular mechanisms of nanoparticle toxicity are largely unexplored. METHODS: Acute lung injury was induced in wild-type mice and angiotensin-coverting enzyme 2 (ACE2) knockout mice by the intratracheal instillation of cationic polyamidoamine dendrimer (PAMAM) nanoparticles. For rescue experiments, losartan (15 mg/kg in PBS) was injected intraperitoneally 30 min before nanoparticle administration. RESULTS: Some PAMAM nanoparticles, but not anionic PAMAM nanoparticles or carbon nanotubes, triggered acute lung failure in mice. Mechanistically, cationic nanoparticles can directly bind ACE2, decrease its activity and down-regulate its expression level in lung tissue, resulting in deregulation of the renin-angiotensin system. Gene inactivation of Ace2 can exacerbate lung injury. Importantly, the administration of losartan, which is an angiotensin II type I receptor antagonist, can ameliorate PAMAM nanoparticle-induced lung injury. CONCLUSIONS: Our data provide molecular insight into PAMAM nanoparticle-induced lung injury and suggest potential therapeutic and screening strategies to address the safety of nanomaterials. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12989-015-0080-x) contains supplementary material, which is available to authorized users.
has issue date	2015-03-07(xsd:dateTime)
bibo:doi	10.1186/s12989-015-0080-x
bibo:pmid	25890286
has license	cc-by
sha1sum (hex)	1b42f78eee63e2f5c5a58a59759dc119ef1f73da
schema:url	https://doi.org/10.1186/s12989-015-0080-x
resource representing a document's title	Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice
has PubMed Central identifier	PMC4395934
has PubMed identifier	25890286
schema:publication	Part Fibre Toxicol
resource representing a document's body	covid:1b42f78eee63e2f5c5a58a59759dc119ef1f73da#body_text
is schema:about of	named entity 'INDUCE' named entity 'Background' named entity 'acute' named entity 'molecular mechanisms' named entity 'lung injury' named entity 'provide' named entity 'molecular' named entity 'tissue' named entity 'screening' named entity 'induce' named entity 'MICE' named entity 'TECHNOLOGY' named entity 'INDUSTRIES' named entity 'LARGELY' named entity 'RECEPTOR ANTAGONIST' named entity 'ACTIVITY' named entity 'ITS' named entity 'LUNG INJURY' named entity 'KNOCKOUT MICE' named entity 'RESULTS' named entity 'CONCLUSIONS' named entity 'II TYPE' named entity 'REPORTS' named entity 'ACUTE LUNG INJURY' named entity 'POTENTIAL' named entity 'MULTIPLE' named entity 'DECREASE' named entity 'EXPERIMENTS' named entity 'TOXICITY' named entity 'BIND' named entity 'ANGIOTENSIN' named entity 'FAILURE' named entity 'INSIGHT' named entity 'ENZYME' named entity 'BUT' named entity 'INTRATRACHEAL INSTILLATION' named entity 'PARTICULAR' named entity 'ACE2' named entity 'CARBON NANOTUBES' named entity 'GROWING' named entity 'LOSARTAN' named entity 'ANGIOTENSIN II' named entity 'DIRECTLY' named entity 'PBS' named entity 'REGULATE' named entity 'SAFETY' named entity 'NANOPARTICLE' named entity 'DENDRIMER' named entity 'DATA' named entity 'MOLECULAR' named entity 'RENIN-ANGIOTENSIN SYSTEM' named entity 'HUMANS' named entity 'EXPRESSION LEVEL' named entity 'BIND' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'MICE' named entity '30 MIN' named entity 'ACUTE LUNG INJURY' named entity 'DIRECTLY' named entity 'HAVE'

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