About: Alveolar macrophages in allergic asthma: An expression signature characterized by heat shock protein pathways

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Alveolar macrophages in allergic asthma: An expression signature characterized by heat shock protein pathways
Creator	Laprise, Catherine Laviolette, Michel Madore, Anne-Marie Bissonnette, Y Perron, Stêphanie Turmel, Vêronique
Source	Elsevier; Medline; PMC
abstract	Abstract The implication of alveolar macrophages (AM) in asthma, a Th2 disease, has not been well characterized. Thus, the goal of this study is to better characterize AM phenotype of allergic asthmatic compared with normal subjects using genomic expression analyses. Microarray analyses were performed with AM isolated from bronchoalveolar lavage. Robust multiarray analysis (RMA) normalization and Smyth's moderated t test were used to select differentially expressed genes. Fifty differentially expressed genes were identified. Nineteen have been classified in categories linked to stress or immune responses and among them; nine are part of the heat shock protein (HSP) family. Difference of expression for three (HSPD1, PRNP, SERPINH1) of the five selected genes were validated using real-time reverse transcription–polymerase chain reaction. Enzyme-linked immunosorbent assay was used to measure the protein level of heat shock protein 60 (HSP60), the protein encoded by HSPD1, and showed difference in AM protein level between allergic asthmatic and control subjects. In summary, this study suggests that HSP gene family, particularly HSP60, is involved in AM functions in a context of allergic asthma. These results also support the involvement of AM immune functions in the development of an allergic asthmatic response.
has issue date	2010-02-28(xsd:dateTime)
bibo:doi	10.1016/j.humimm.2009.11.005
bibo:pmid	19913588
has license	els-covid
sha1sum (hex)	1a942c4423ddefe5cd28d91cf2feb0c8875e8ab8
schema:url	https://doi.org/10.1016/j.humimm.2009.11.005
resource representing a document's title	Alveolar macrophages in allergic asthma: An expression signature characterized by heat shock protein pathways
has PubMed Central identifier	PMC7124256
has PubMed identifier	19913588
schema:publication	Human Immunology
resource representing a document's body	covid:1a942c4423ddefe5cd28d91cf2feb0c8875e8ab8#body_text
is schema:about of	named entity 'expressed genes' named entity 'HSPD1' named entity 'reverse' named entity 'macrophages' named entity 'PHENOTYPE' named entity 'SELECT' named entity 'ALLERGIC ASTHMA' named entity 'ALLERGIC ASTHMA' named entity 'RESULTS' named entity 'DEVELOPMENT' named entity 'H 2' named entity 'IMMUNE RESPONSES' named entity 'REVERSE TRANSCRIPTION' named entity 'STUDY' named entity 'POLYMERASE CHAIN REACTION' named entity 'ALLERGIC' named entity 'EXPRESSED' named entity 'PART OF' named entity 'INVOLVEMENT' named entity 'SUBJECTS' named entity 'HSPD1' named entity 'FIFTY' named entity 'HEAT SHOCK PROTEIN' named entity '27S' named entity 'IMMUNOSORBENT' named entity 'PROTEIN ' named entity 'PRNP' named entity 'EXPRESSION' named entity 'ROBUST' named entity 'NORMALIZATION' named entity 'MICROARRAY' named entity 'CONTROL' named entity 'ISOLATED' named entity 'STRESS' named entity 'SMYTH' named entity 'CLASSIFIED' named entity 'PERFORMED' named entity 'GENE FAMILY' named entity 'REAL-TIME' named entity 'ASTHMA' named entity 'GOAL' named entity 'A T' named entity 'GENES' named entity 'NORMAL' named entity 'PATHWAYS' named entity 'ALVEOLAR MACROPHAGES' named entity 'EXPRESSION SIGNATURE' named entity 'CATEGORIES' named entity 'HEAT SHOCK PROTEIN 60' named entity 'ANALYSIS' named entity 'FUNCTIONS' named entity 'BRONCHOALVEOLAR LAVAGE' named entity 'CHARACTERIZED' named entity 'HSP' named entity 'HEAT SHOCK PROTEIN' named entity 'PROTEIN ' named entity 'DIFFERENCE' named entity 'DISEASE' named entity 'RESPONSE' named entity 'ENCODED' named entity 'PROTEIN LEVEL' named entity 'NINETEEN' named entity 'CHARACTERIZED' named entity 'VALIDATED' named entity 'IDENTIFIED' named entity 'IMMUNE' named entity 'FAMILY' named entity 'INVOLVED' named entity 'SUPPORT' named entity 'ASSAY' named entity 'T TEST' named entity 'THESE' named entity 'HAVE' named entity 'ASTHMATIC' named entity 'USING' named entity 'ALVEOLAR MACROPHAGES'

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