About: Deconvoluting Virome-Wide Antiviral Antibody Profiling Data

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Deconvoluting Virome-Wide Antiviral Antibody Profiling Data Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Deconvoluting Virome-Wide Antiviral Antibody Profiling Data
Creator	Wang, Lin-Fa Anderson, Danielle Chia, Wan Wijaya, Limin Breitwieser, Florian Caturegli, Mario Kammers, Kai Kottapalli, Sanjay Larman, H Monaco, Daniel Rewers, Marian Tan, Kevin Waugh, Kathleen Yuan, Tiezheng
source	BioRxiv; MedRxiv
abstract	The ability to comprehensively characterize exposures and immune responses to viral infections will be critical to better understanding human health and disease. We previously described the VirScan system, a phage-display based technology for profiling antibody binding to a comprehensive library of peptides designed to represent the human virome. The previous VirScan analytical approach did not fully account for disproportionate representation of viruses in the library or for antibody cross-reactivity among sequences shared by related viruses. Here we present the ‘AntiViral Antibody Response Deconvolution Algorithm’ (‘AVARDA’), a multi-module software package for analyzing VirScan datasets. AVARDA provides a probabilistic assessment of infection at species-level resolution by considering alignment of all library peptides to each other and to all human viruses. We employed AVARDA to analyze VirScan data from a cohort of encephalitis patients with either known viral infections or undiagnosed etiologies. By comparing acute and convalescent sera, AVARDA successfully confirmed or detected antibody responses to human herpesviruses 1, 3, 4, 5, and 6, thereby improving the rate of diagnosing viral encephalitis in this cohort by 62.5%. We further assessed AVARDA’s utility in the setting of an epidemiological study, demonstrating its ability to determine infections acquired in a child followed prospectively from infancy. We consider ways in which AVARDA’s conceptual framework may be further developed in the future and describe how its analyses may be extended beyond investigations of viral infection. AVARDA, in combination with VirScan and other pan-pathogen serological techniques, is likely to find broad utility in the epidemiology and diagnosis of infectious diseases.
has issue date	2018-05-30(xsd:dateTime)
bibo:doi	10.1101/333625
has license	biorxiv
sha1sum (hex)	1a75c4ef6fba1554a76ab7a8addaedfefc230aec
schema:url	https://doi.org/10.1101/333625
resource representing a document's title	Deconvoluting Virome-Wide Antiviral Antibody Profiling Data
schema:publication	bioRxiv
resource representing a document's body	covid:1a75c4ef6fba1554a76ab7a8addaedfefc230aec#body_text
is schema:about of	named entity 'diagnosis' named entity 'datasets' named entity 'employed' named entity 'represent' named entity 'prospectively' named entity 'COMPREHENSIVE' named entity 'RELATED' named entity 'MULTI' named entity 'ABILITY TO' named entity 'PREVIOUSLY' named entity 'PRESENT' named entity '62.5' named entity 'SETTING' named entity 'PACKAGE' named entity 'Antibody' named entity 'conceptual framework' named entity 'viruses' named entity 'comparing' named entity 'future' named entity 'library' named entity 'ways' named entity 'confirmed' named entity 'library' named entity 'investigations' named entity 'convalescent' named entity 'Here' named entity 'utility' named entity 'etiologies' named entity 'epidemiology' named entity 'cohort' named entity 'Antiviral' named entity 'peptides' named entity 'viral infections' named entity 'human virome' named entity 'viral infections' named entity 'serological' named entity 'antibody' named entity 'human health' named entity 'viruses' named entity 'viruses' named entity 'AntiViral' named entity 'Antiviral' named entity 'peptides' named entity 'convalescent serum' named entity 'peptide' named entity 'antibody' named entity 'peptides' named entity 'peptides' named entity 'red cross' named entity 'EBV infection' named entity 'viruses' named entity 'proportional representation' named entity 'IgG' named entity 'peptides' named entity 'infective organism' named entity 'antibody' named entity 'viruses' named entity 'peptides' named entity 'peptides' named entity 'antibody testing' named entity 'herpes simplex virus' named entity 'Khoo Teck Puat Hospital' named entity 'informs' named entity 'Rhinovirus' named entity 'neurological' named entity 'peptides' named entity 'peptides' named entity 'scatterplot' named entity 'peptides' named entity 'peptide' named entity 'serological'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software