About: The role of visceral adiposity in the severity of COVID-19: highlights from a unicenter cross-sectional pilot study in Germany

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About: The role of visceral adiposity in the severity of COVID-19: highlights from a unicenter cross-sectional pilot study in Germany Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The role of visceral adiposity in the severity of COVID-19: highlights from a unicenter cross-sectional pilot study in Germany
Creator	Adams, Lisa Albrecht, Jakob Bressem, Keno Hamm, Bernd Makowski, Marcus Niehues, Alexandra Niehues, Stefan Petersen, Antonia Thieß, Hans-Martin Vahldiek, Janis
source	Elsevier; Medline; PMC
abstract	BACKGROUND AND AIMS. Overall obesity has recently been established as an independent risk factor for critical illness in patients with coronavirus disease 2019 (COVID-19). The role of fat distribution and especially that of visceral fat, which is often associated with metabolic syndrome, remains unclear. Therefore, this study aims at investigating the association between fat distribution and COVID-19 severity. METHODS: Thirty patients with COVID-19 and a mean age of 65.6 ± 13.1 years from a level-one medical center in Berlin, Germany, were included in the present cross-sectional analysis. COVID-19 was confirmed by polymerase chain reaction (PCR) from nasal and throat swabs. A severe clinical course of COVID-19 was defined by hospitalization in the intensive care unit (ICU) and/or invasive mechanical ventilation. Fat was measured at the level of the first lumbar vertebra on routinely acquired low-dose chest computed tomography (CT). RESULTS: An increase in visceral fat area (VFA) by ten square centimeters was associated with a 1.37-fold higher likelihood of ICU treatment and a 1.32-fold higher likelihood of mechanical ventilation (adjusted for age and sex). For upper abdominal circumference, each additional centimeter of circumference was associated with a 1.13-fold higher likelihood of ICU treatment and a 1.25-fold higher likelihood of mechanical ventilation. CONCLUSIONS: Our proof-of-concept study suggests that visceral adipose tissue and upper abdominal circumference specifically increase the likelihood of COVID-19 severity. CT-based quantification of visceral adipose tissue and upper abdominal circumference in routine chest CTs may therefore be a simple tool for risk assessment in COVID-19 patients.
has issue date	2020-07-14(xsd:dateTime)
bibo:doi	10.1016/j.metabol.2020.154317
bibo:pmid	32673651
has license	no-cc
sha1sum (hex)	1a1ab856aba48ef5b149351e7b0b0efbac600032
schema:url	https://doi.org/10.1016/j.metabol.2020.154317
resource representing a document's title	The role of visceral adiposity in the severity of COVID-19: highlights from a unicenter cross-sectional pilot study in Germany
has PubMed Central identifier	PMC7358176
has PubMed identifier	32673651
schema:publication	Metabolism
resource representing a document's body	covid:1a1ab856aba48ef5b149351e7b0b0efbac600032#body_text
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