About: Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China

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About: Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China
Creator	Xiong, Yong Cao, Qian Chen, Tielong Chen, Xiaoping Cheng, Zhenshun Deng, Liping Gao, Shicheng Liang, Ke Luo, Mingqi Ma, Zhiyong Mo, Pingzheng Song, Shihui Wang, Fan Wang, Hongling Xiao, Yu Xing, Yuanyuan Zhang, Yongxi Zhao, Qiu Zheng, Ruiying
Source	Medline; PMC
abstract	BACKGROUND: Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. This study aimed to clarify the characteristics of patients with refractory COVID-19. METHODS: In this retrospective single-center study, we included 155 consecutive patients with confirmed COVID-19 in Zhongnan Hospital of Wuhan University from January 1(st) to February 5(th). The cases were divided into general and refractory COVID-19 groups according to the clinical efficacy after hospitalization, and the difference between groups were compared. RESULTS: Compared with general COVID-19 patients (45.2%), refractory patients had an older age, male sex, more underlying comorbidities, lower incidence of fever, higher levels of maximum temperature among fever cases, higher incidence of breath shortness and anorexia, severer disease assessment on admission, high levels of neutrophil, aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and C-reactive protein, lower levels of platelets and albumin, and higher incidence of bilateral pneumonia and pleural effusion (P<0.05). Refractory COVID-19 patients were more likely to receive oxygen, mechanical ventilation, expectorant, and adjunctive treatment including corticosteroid, antiviral drugs and immune enhancer (P<0.05). After adjustment, those with refractory COVID-19 were also more likely to have a male sex and manifestations of anorexia and fever on admission, and receive oxygen, expectorant and adjunctive agents (P<0.05) when considering the factors of disease severity on admission, mechanical ventilation, and ICU transfer. CONCLUSION: Nearly 50% COVID-19 patients could not reach obvious clinical and radiological remission within 10 days after hospitalization. The patients with male sex, anorexia and no fever on admission predicted poor efficacy.
has issue date	2020-03-16(xsd:dateTime)
bibo:doi	10.1093/cid/ciaa270
bibo:pmid	32173725
has license	no-cc
sha1sum (hex)	19aae9da84740cdf1c0a7e8c68c865cb6aedf386
schema:url	https://doi.org/10.1093/cid/ciaa270
resource representing a document's title	Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China
has PubMed Central identifier	PMC7184444
has PubMed identifier	32173725
schema:publication	Clin Infect Dis
resource representing a document's body	covid:19aae9da84740cdf1c0a7e8c68c865cb6aedf386#body_text
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