About: Recombination between North American strains of porcine reproductive and respiratory syndrome virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Recombination between North American strains of porcine reproductive and respiratory syndrome virus
Creator	Yuan, Shishan Murtaugh, Michael Faaberg, Kay Nelsen, Chris Schmitt, Beverly
source	Elsevier; Medline; PMC
abstract	Abstract Porcine reproductive and respiratory syndrome virus (PRRSV), a recently discovered arterivirus swine pathogen, was shown to undergo homologous recombination. Co-infection of MA-104 cells with two culture-adapted North American PRRSV strains resulted in recombinant viral particles containing chimeric ORF 3 and ORF 4 proteins. Nucleotide sequence analysis of cloned recombinant PCR products, encompassing 1182 bases of the 15.4 kb viral genome, revealed six independent recombination events. Recombinant products persisted in culture for at least three passages, indicating continuous formation of recombinant viruses, growth of recombinant viruses in competition with parental viruses, or both. The frequency of recombination was estimated from <2% up to 10% in the 1182 b fragment analyzed, which is similar to recombination frequencies observed in coronaviruses. An apparent example of natural ORF 5 recombination between naturally occurring wild type viruses was also found, indicating that recombination is likely an important genetic mechanism contributing to PRRSV evolution.
has issue date	1999-05-31(xsd:dateTime)
bibo:doi	10.1016/s0168-1702(99)00029-5
bibo:pmid	10426212
has license	els-covid
sha1sum (hex)	1895d31fcb3c610e7ceb51e2fdafe67f865f15c1
schema:url	https://doi.org/10.1016/s0168-1702%2899%2900029-5
resource representing a document's title	Recombination between North American strains of porcine reproductive and respiratory syndrome virus
has PubMed Central identifier	PMC7125646
has PubMed identifier	10426212
schema:publication	Virus Research
resource representing a document's body	covid:1895d31fcb3c610e7ceb51e2fdafe67f865f15c1#body_text
is schema:about of	named entity 'STRAINS' named entity 'NORTH AMERICAN' named entity 'EVOLUTION' named entity 'APPARENT' named entity 'CONTRIBUTING' »more»

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