About: Characterization and expression of DEC205 in the cDC1 and cDC2 subsets of porcine dendritic cells from spleen, tonsil, and submaxillary and mesenteric lymph nodes

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About: Characterization and expression of DEC205 in the cDC1 and cDC2 subsets of porcine dendritic cells from spleen, tonsil, and submaxillary and mesenteric lymph nodes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization and expression of DEC205 in the cDC1 and cDC2 subsets of porcine dendritic cells from spleen, tonsil, and submaxillary and mesenteric lymph nodes
Creator	Hernández, Jesús Parra-Sánchez, Héctor Puebla-Clark, Lucinda Reséndiz, Mónica Valenzuela, Olivia
Source	Elsevier; Medline; PMC
abstract	Abstract Conventional dendritic cells (cDCs) are divided into the following different subtypes: cDC1, which promotes a Th1 response, and cDC2, which stimulates a Th2 and Th17 response. These cells have not been characterized in porcine lymphoid tissues. DEC205 is a receptor that increases antigen presentation and allows DCs to cross-present antigens. The objectives of this work were to characterize cDCs subsets in the tonsil, submaxillary and mesenteric lymph nodes and spleen lymphoid tissues and to determine their expression of DEC205 by flow cytometry. The cDC1 (MHCIIhighCADM1highCD172a−/low) and cDC2 (MHCIIhighCADM1highCD172a+) phenotypes were confirmed by the expression of characteristic cDC1 and cDC2 transcripts (FLT3, XCR1 and FCER1α). Among all lymphoid tissues, the spleen had the highest frequency of total cDCs. The cDC1:cDC2 ratio showed that all lymph tissues had higher levels of cDC1 than levels of cDC2. DEC205+ cDCs were found in all analyzed tissues, albeit with different frequencies. Our research will facilitate the study on the function of these cells and the investigation of the strategies for DEC205 targeting and functional studies.
has issue date	2018-04-30(xsd:dateTime)
bibo:doi	10.1016/j.molimm.2018.02.003
bibo:pmid	29433077
has license	els-covid
sha1sum (hex)	17d5ae159dfe162ac57318232144b103e79e0f1c
schema:url	https://doi.org/10.1016/j.molimm.2018.02.003
resource representing a document's title	Characterization and expression of DEC205 in the cDC1 and cDC2 subsets of porcine dendritic cells from spleen, tonsil, and submaxillary and mesenteric lymph nodes
has PubMed Central identifier	PMC7112646
has PubMed identifier	29433077
schema:publication	Molecular Immunology
resource representing a document's body	covid:17d5ae159dfe162ac57318232144b103e79e0f1c#body_text
is schema:about of	named entity 'PORCINE' named entity 'spleen' named entity 'DENDRITIC CELLS' named entity 'LYMPHOID TISSUES' named entity 'SUBMAXILLARY' named entity 'FREQUENCY' named entity 'DIFFERENT' named entity 'PORCINE' named entity 'DEC205' named entity 'TISSUES' named entity 'LYMPH' named entity 'FUNCTION' named entity 'DENDRITIC CELLS' named entity 'XCR1' named entity 'RESPONSE' named entity 'DETERMINE' named entity 'WORK' named entity 'TRANSCRIPTS' named entity 'MESENTERIC LYMPH NODES' named entity 'OUR' named entity 'TARGETING' named entity 'DIVIDED' named entity 'ALLOWS' named entity 'FOLLOWING' named entity 'TH17' named entity 'ANTIGENS' named entity 'SUBMAXILLARY' named entity 'CDC2' named entity 'CELLS' covid:arg/17d5ae159dfe162ac57318232144b103e79e0f1c named entity 'THESE' named entity 'RATIO' named entity 'RESEARCH' named entity 'ANALYZED' named entity 'FREQUENCIES' named entity 'FOUND' named entity 'CHARACTERISTIC' named entity 'CADM1' named entity 'CHARACTERIZED' named entity 'HIGHEST' named entity 'TO CHARACTERIZE' named entity 'DCS' named entity 'EXPRESSION' named entity 'OBJECTIVES' named entity 'INCREASES' named entity 'CHARACTERIZATION' named entity 'CDC1' named entity 'EXPRESSION' named entity 'DEC205' named entity 'FLOW CYTOMETRY' named entity 'STUDIES' named entity 'FUNCTIONAL' named entity 'CDC2' named entity 'SPLEEN' named entity 'TOTAL' named entity 'SUBTYPES' named entity 'PHENOTYPES' named entity 'STUDY' named entity 'IS A' named entity 'ANTIGEN PRESENTATION' named entity 'CD172A' named entity 'TH2' named entity 'TONSIL' named entity 'INVESTIGATION' named entity 'TONSIL' named entity 'SPLEEN' named entity 'MESENTERIC LYMPH NODES' named entity 'CDC1' named entity 'TH1 RESPONSE' named entity 'CONFIRMED BY' named entity 'HIGH' named entity 'STRATEGIES' named entity 'RECEPTOR' named entity 'CONVENTIONAL' named entity 'THEIR' named entity 'LEVELS' named entity 'HAVE'

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