About: Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin

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About: Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin
Creator	Zmora, Pawel Braun, Armin Brinkmann, Constantin Curths, Christoph Dahlmann, Franziska Dehmel, Susann Gruber, Jens Hartleib, Anika Knauf, Sascha Konzok, Sebastian Molau-Blazejewska, Paulina Moldenhauer, Anna-Sophie Mätz-Rensing, Kerstin Nehlmeier, Inga Sewald, Katherina Walendy-Gnirß, Kerstin Pö Hlmann, Stefan Bertram,
source	Medline; PMC
abstract	The cellular serine protease TMPRSS2, a member of the type II transmembrane serine protease (TTSP) family, cleaves and activates the hemagglutinin of influenza A viruses (FLUAV) in cell culture and is essential for spread of diverse FLUAV in mice. Non-human primates (NHP), in particular rhesus and cynomolgus macaques, serve as animal models for influenza and experimental FLUAV infection of common marmosets has recently also been reported. However, it is currently unknown whether the NHP orthologues of human TMPRSS2 cleave and activate FLUAV hemagglutinin and contribute to viral spread in respiratory tissue. Here, we cloned and functionally analyzed the macaque and marmoset orthologues of human TMPRSS2. In addition, we analyzed the macaque orthologues of human TMPRSS4 and HAT, which also belong to the TTSP family. We found that all NHP orthologues of human TMPRSS2, TMPRSS4 and HAT cleave and activate HA upon directed expression and provide evidence that endogenous TMPRSS2 is expressed in the respiratory epithelium of rhesus macaques. Finally, we demonstrate that a serine protease inhibitor active against TMPRSS2 suppresses FLUAV spread in precision-cut lung slices of human, macaque and marmoset origin. These results indicate that FLUAV depends on serine protease activity for spread in diverse NHP and in humans. Moreover, our findings suggest that macaques and marmosets may serve as models to study FLUAV activation by TMPRSS2 in human patients.
has issue date	2017-05-11(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0176597
bibo:pmid	28493964
has license	cc-by
sha1sum (hex)	17413f651645c2b9c92555e9ce1404b9290eccab
schema:url	https://doi.org/10.1371/journal.pone.0176597
resource representing a document's title	Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin
has PubMed Central identifier	PMC5426610
has PubMed identifier	28493964
schema:publication	PLoS One
resource representing a document's body	covid:17413f651645c2b9c92555e9ce1404b9290eccab#body_text
is schema:about of	named entity 'TMPRSS2' named entity 'NHP' named entity 'essential' named entity 'human' named entity 'Project' named entity 'KWG' named entity 'orthologues' named entity 'influenza' named entity 'hemagglutinin' named entity 'NON-HUMAN PRIMATE' named entity 'ACTIVATE' named entity 'PRIMATES' named entity 'MACAQUE' covid:arg/17413f651645c2b9c92555e9ce1404b9290eccab named entity 'UNKNOWN' named entity 'EVIDENCE' named entity 'EXPRESSION' named entity 'RECENTLY' named entity 'LUNG' named entity 'FLUAV' named entity 'TTSP' named entity 'ORIGIN' named entity 'FUNDING' named entity 'COMMON' named entity 'MEMBER OF' named entity 'SUPPRESSES' named entity 'RESOURCES' named entity 'CONCEPTUALIZATION' named entity 'ADMINISTRATION' named entity 'PROJECT' named entity 'FOUND' named entity 'ASM' named entity 'MICE' named entity 'INVESTIGATION' named entity 'SERINE PROTEASE ACTIVITY' named entity 'RHESUS MACAQUES' named entity 'OUR' named entity 'CELL CULTURE' named entity 'TMPRSS2' named entity 'INFLUENZA VIRUS' named entity 'SUGGEST' named entity 'CUT' named entity 'PRECISION' named entity 'ANALYSIS' named entity 'TISSUE' named entity 'ACTIVE' named entity 'HEMAGGLUTININ' named entity 'STUDY' named entity 'NHP' named entity 'FAMILY' named entity 'ACTIVATION' named entity 'INFLUENZA' named entity 'SPREAD' named entity 'MACAQUES' named entity 'TMPRSS4' named entity 'CELLULAR' named entity 'DIVERSE' named entity 'ACTIVATES' named entity 'CURRENTLY' named entity 'MODELS' named entity 'ACTIVATE' named entity 'EXPRESSED' named entity 'RHESUS' named entity 'PMB'

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