About: 2’-Fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705

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About: 2’-Fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	2’-Fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705
Creator	Li, Yang Peppelenbosch, Maikel Pan, · Wang, Yining Li, Yunlong Miao, Zhijiang Yu, Peifa
Source	PMC
abstract	Noroviruses are the main causative agents of acute viral gastroenteritis worldwide. However, no vaccine or specific antiviral treatment is available, imposing a heavy global health burden. The nucleoside analogue 2’-fluoro-2’-deoxycytidine (2’-FdC) has been reported to have broad antiviral activity. Here, we report that 2’-FdC significantly inhibits murine norovirus replication in macrophages. This effect was partially reversed by exogenous supplementation of cytidine triphosphate. The combination of 2’-FdC with mycophenolic acid, ribavirin or favipiravir (T705) exerts synergistic antiviral effects. These results indicate that 2’-FdC is a potential candidate for antiviral drug development against norovirus infection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00705-020-04759-4) contains supplementary material, which is available to authorized users.
has issue date	2020-08-08(xsd:dateTime)
bibo:doi	10.1007/s00705-020-04759-4
bibo:pmid	32770483
has license	cc-by
sha1sum (hex)	16ef6186587e7b7d86675daa67977079c2cf2839
schema:url	https://doi.org/10.1007/s00705-020-04759-4
resource representing a document's title	2’-Fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705
has PubMed Central identifier	PMC7414258
has PubMed identifier	32770483
schema:publication	Arch Virol
resource representing a document's body	covid:16ef6186587e7b7d86675daa67977079c2cf2839#body_text
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