About: Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese

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About: Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese
Creator	Liu, Cheng Ding, Wenjun Du, Fengjiao He, Tao Liu, Huiliang Ma, Dongxing Mei, Zhiqin Rong, Yanxiao Wang, Haibin Wang, Yuling Wei, Yujie Wu, Xueqiong Zhang, Zongde Zheng, Li Zhu, Yuehua
Source	PMC
abstract	Tuberculosis (TB) is caused by infection of Mycobacterium tuberculosis. Host genetic variability is an important determinant of the risk of developing TB in humans. Although the association between MBL2 polymorphisms and TB has been studied in various populations, the results are controversial. In this study four functional single-nucleotide polymorphisms (SNPs, H/L, X/Y, P/Q and A/B) across the MBL2 gene were genotyped by direct DNA sequencing of PCR products in a case-control population of Chinese Han origin, consisting of 1,020 patients with pulmonary TB and 1,020 controls. We found that individuals carrying variant allele at A/B (namely BB or AB genotypes) was associated with increased susceptibility to TB (odds ratios [OR] = 1.57, 95% confidence interval [CI] 1.30–1.91, P = 1.3 × 10(−6)). Additionally, LYPB haplotype showed a significant association with increased risk of TB (OR = 1.54, 95% CI 1.27–1.87, P = 4.2 × 10(−6); global haplotype association P = 3.5 × 10(−5)). Furthermore, individuals bearing low- or medium- MBL expression haplotype pairs had an increased risk of TB (OR = 1.56, 95% CI 1.29–1.90, P = 1.4 × 10(−6)). Thus, the reduced expression of functional MBL secondary to having MBL2 variants may partially mediate the increased susceptibility to TB risk.
has issue date	2016-11-04(xsd:dateTime)
bibo:doi	10.1038/srep36488
bibo:pmid	27812036
has license	cc-by
sha1sum (hex)	1621345a6fa32695580f1455de8a7f6284a0f9e9
schema:url	https://doi.org/10.1038/srep36488
resource representing a document's title	Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese
has PubMed Central identifier	PMC5095599
has PubMed identifier	27812036
schema:publication	Sci Rep
resource representing a document's body	covid:1621345a6fa32695580f1455de8a7f6284a0f9e9#body_text
is schema:about of	named entity 'OPEN' named entity 'MBL2' named entity 'expression' named entity 'Thus' named entity 'risk' named entity 'SNPs' named entity '95% CI' named entity 'case-control' named entity 'polymorphisms' named entity 'ASSOCIATION' named entity 'LOW' named entity 'REDUCED' named entity 'INDIVIDUALS' named entity 'MBL' named entity 'TUBERCULOSIS' named entity 'RESULTS' named entity 'PARTIALLY' named entity 'SECONDARY TO' named entity 'HAN' named entity 'RISK OF' named entity 'FUNCTIONAL' named entity 'INCREASED RISK' named entity 'DNA SEQUENCING' named entity 'CARRYING' named entity 'CHINESE' named entity '2FB' named entity 'BEARING' named entity 'VARIANT ALLELE' named entity 'PATIENTS' named entity 'ORIGIN' named entity 'SIGNIFICANT' named entity 'INCREASED SUSCEPTIBILITY' named entity 'VARIOUS' named entity '1.3' named entity '3.5' named entity 'MBL2' named entity 'POLYMORPHISMS' named entity 'MBL2 GENE' named entity 'HAPLOTYPE' named entity '4.2' named entity 'MANNOSE-BINDING LECTIN' named entity 'CHINESE' named entity '90%' named entity 'PRODUCTS' named entity 'PULMONARY TB' named entity 'POPULATIONS' named entity 'DIRECT' named entity '926' named entity 'GLOBAL' named entity 'ASSOCIATION' named entity 'MEDIUM' named entity 'EXPRESSION' named entity 'FOUND' named entity 'ACROSS' named entity 'VARIANTS' named entity '1.56' named entity 'CONTROL POPULATION' named entity 'POLYMORPHISMS' named entity 'RATIOS' named entity 'SUSCEPTIBILITY' named entity 'STUDY' named entity 'CONFIDENCE INTERVAL' named entity 'CASE-CONTROL' named entity 'GENOTYPES' named entity 'ASSOCIATED WITH' named entity 'PAIRS' named entity '1.4'

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