About: Transmissible Gastroenteritis Virus Infection Enhances SGLT1 and GLUT2 Expression to Increase Glucose Uptake

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transmissible Gastroenteritis Virus Infection Enhances SGLT1 and GLUT2 Expression to Increase Glucose Uptake
Creator	Yang, Qian Hu, Wei Dai, Lei Xia, Lu Xia, Mi
Source	Medline; PMC
abstract	Transmissible gastroenteritis virus (TGEV) is a coronavirus that causes villus atrophy, followed by crypt hyperplasia, reduces the activities of intestinal digestive enzymes, and disrupts the absorption of intestinal nutrients. In vivo, TGEV primarily targets and infects intestinal epithelial cells, which play an important role in glucose absorption via the apical and basolateral transporters Na(+)-dependent glucose transporter 1 (SGLT1) and facilitative glucose transporter 2 (GLUT2), respectively. In this study, we therefore sought to evaluate the effects of TGEV infection on glucose uptake and SGLT1 and GLUT2 expression. Our data demonstrate that infection with TGEV resulted in increased glucose uptake and augmented expression of EGFR, SGLT1 and GLUT2. Moreover, inhibition studies showed that EGFR modulated glucose uptake in control and TGEV infected cells. Finally, high glucose absorption was subsequently found to promote TGEV replication.
has issue date	2016-11-16(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0165585
bibo:pmid	27851758
has license	cc-by
sha1sum (hex)	15a5a243bb623a17ee4f0c18c4e3bea8c065ed11
schema:url	https://doi.org/10.1371/journal.pone.0165585
resource representing a document's title	Transmissible Gastroenteritis Virus Infection Enhances SGLT1 and GLUT2 Expression to Increase Glucose Uptake
has PubMed Central identifier	PMC5112927
has PubMed identifier	27851758
schema:publication	PLoS One
resource representing a document's body	covid:15a5a243bb623a17ee4f0c18c4e3bea8c065ed11#body_text
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