About: Mannose‐binding lectin in innate immunity: past, present and future

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Mannose‐binding lectin in innate immunity: past, present and future Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mannose‐binding lectin in innate immunity: past, present and future
Creator	Klein, N Turner, M Turner, Malcolm Dommett, R
Source	Medline; PMC
abstract	The human collectin, mannose‐binding lectin (MBL), is an important protein of the humoral innate immune system. With multiple carbohydrate‐recognition domains, it is able to bind to sugar groups displayed on the surfaces of a wide range of microorganisms and thereby provide first‐line defence. Importantly, it also activates the complement system through a distinctive third pathway, independent of both antibody and the C1 complex. Three single point mutations in exon 1 of the expressed human MBL‐2 gene appear to impair the generation of functional oligomers. Such deficiencies of functional protein are common in certain populations, e.g. in sub‐Saharan Africa, but virtually absent in others, e.g. indigenous Australians. MBL disease association studies have been a fruitful area of research and implicate a role for MBL in infective, inflammatory and autoimmune disease processes. Overall, there appears to be a genetic balance in which individuals generally benefit from high levels of the protein. However, in certain situations, reduced levels of circulating MBL may be beneficial to the host and this may explain the persistence of the deleterious gene polymorphisms in many population groups.
has issue date	2006-09-01(xsd:dateTime)
bibo:doi	10.1111/j.1399-0039.2006.00649.x
bibo:pmid	16948640
has license	no-cc
sha1sum (hex)	1468d0bcf3c567c4b3a7cb87cea974c8642f9669
schema:url	https://doi.org/10.1111/j.1399-0039.2006.00649.x
resource representing a document's title	Mannose‐binding lectin in innate immunity: past, present and future
has PubMed Central identifier	PMC7169806
has PubMed identifier	16948640
schema:publication	Tissue Antigens
resource representing a document's body	covid:1468d0bcf3c567c4b3a7cb87cea974c8642f9669#body_text
is schema:about of	named entity 'exon' named entity 'persistence' named entity 'gene' named entity 'expressed' named entity 'groups' named entity 'circulating' named entity 'domains' named entity 'antibody' named entity 'population' named entity 'populations' named entity 'bind' named entity 'virtually' named entity 'provide' named entity 'infective' named entity 'exon' named entity 'carbohydrate' named entity 'oligomers' named entity 'indigenous Australians' named entity 'C1 complex' named entity 'MBL' named entity 'autoimmune disease' named entity 'microorganisms' named entity 'inflammatory' named entity 'single point mutations' named entity 'antibody' named entity 'Blackwell Munksgaard' named entity 'reduced levels' named entity 'MBL' named entity 'sub-Saharan Africa' named entity 'protein' named entity 'polymorphisms' named entity 'association studies' named entity 'high levels' named entity 'MBL' named entity 'Three' named entity 'gene' named entity 'mannose-binding lectin' named entity 'CIRCULATING' named entity 'RANGE' named entity 'GENE POLYMORPHISMS' named entity 'DELETERIOUS' named entity 'DISPLAYED' named entity 'HUMAN' named entity 'GENERALLY' named entity 'GROUPS' named entity 'MULTIPLE' named entity 'EXON' named entity 'protein' named entity 'MBL' named entity 'MBL' named entity 'sugar' named entity 'complement' covid:arg/1468d0bcf3c567c4b3a7cb87cea974c8642f9669 named entity 'MBL' named entity 'AUTOIMMUNE DISEASE' named entity 'SUGAR' named entity 'INDIVIDUALS' named entity 'first-line' named entity 'innate immune' named entity 'protein' named entity 'humoral' named entity 'FUNCTIONAL' named entity 'RECOGNITION' named entity 'LINE' named entity 'ABLE TO' named entity 'ACTIVATES' named entity 'STUDIES' named entity 'LEVELS' named entity 'CERTAIN' named entity 'APPEAR' named entity 'gene' named entity 'collectin' named entity 'activates' named entity 'microorganisms' named entity 'wide range' named entity 'MBL' named entity 'complement system' named entity 'protein'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software