About: Interleukin 35: A Key Mediator of Suppression and the Propagation of Infectious Tolerance

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interleukin 35: A Key Mediator of Suppression and the Propagation of Infectious Tolerance
Creator	Burlingham, William Olson, Brian Sullivan, Jeremy Cobbold, Stephen Elkord, Eyad Kretschmer, Karsten Lombardi, Giovanna
Source	Medline; PMC
abstract	The importance of regulatory T cells (Tregs) in balancing the effector arm of the immune system is well documented, playing a central role in preventing autoimmunity, facilitating graft tolerance following organ transplantation, and having a detrimental impact on the development of anti-tumor immunity. These regulatory responses use a variety of mechanisms to mediate suppression, including soluble factors. While IL-10 and TGF-β are the most commonly studied immunosuppressive cytokines, the recently identified IL-35 has been shown to have potent suppressive function in vitro and in vivo. Furthermore, not only does IL-35 have the ability to directly suppress effector T cell responses, it is also able to expand regulatory responses by propagating infectious tolerance and generating a potent population of IL-35-expressing inducible Tregs. In this review, we summarize research characterizing the structure and function of IL-35, examine its role in disease, and discuss how it can contribute to the induction of a distinct population of inducible Tregs.
has issue date	2013-10-18(xsd:dateTime)
bibo:doi	10.3389/fimmu.2013.00315
bibo:pmid	24151492
has license	cc-by
sha1sum (hex)	13d3cd2797da7eb9cc334821680a7b30badafa11
schema:url	https://doi.org/10.3389/fimmu.2013.00315
resource representing a document's title	Interleukin 35: A Key Mediator of Suppression and the Propagation of Infectious Tolerance
has PubMed Central identifier	PMC3798782
has PubMed identifier	24151492
schema:publication	Front Immunol
resource representing a document's body	covid:13d3cd2797da7eb9cc334821680a7b30badafa11#body_text
is schema:about of	named entity 'vivo' named entity 'SUPPRESSION' named entity 'KEY' named entity 'PROPAGATION' named entity 'IN VITRO' named entity 'ORGAN TRANSPLANTATION' named entity 'TUMOR IMMUNITY' named entity 'TOLERANCE' named entity 'IN VIVO' named entity 'GENERATING' named entity 'EFFECTOR' named entity 'DISEASE' named entity 'REVIEW' named entity 'DOCUMENTED' named entity 'ROLE' named entity 'SUPPRESS' named entity 'DIRECTLY' named entity 'FACILITATING' named entity 'GRAFT' named entity 'INFECTIOUS' named entity 'HOW' named entity 'REGULATORY T CELLS' named entity 'ARM' named entity 'AUTOIMMUNITY' named entity 'HAVE' named entity 'SUPPRESSION' named entity 'INTERLEUKIN 35' named entity 'TOLERANCE' named entity 'RECENTLY' named entity 'USE' named entity 'EXPAND' named entity 'STRUCTURE' named entity 'RESEARCH' named entity 'PREVENTING' named entity 'REGULATORY' named entity 'DEVELOPMENT' named entity 'PLAYING' named entity 'CYTOKINES' named entity 'INCLUDING' named entity 'MECHANISMS' named entity 'FUNCTION' named entity 'INDUCTION' named entity 'CENTRAL' named entity 'FOLLOWING' named entity 'TGF' named entity 'CONTRIBUTE ' named entity 'EFFECTOR T CELL' named entity 'POPULATION' named entity 'DOES' named entity 'THESE' named entity 'BALANCING' named entity 'IMMUNOSUPPRESSIVE' named entity 'SOLUBLE' named entity 'MEDIATE' named entity 'DISTINCT' named entity 'VARIETY' named entity 'INDUCIBLE' named entity 'ITS' named entity 'INFECTIOUS' named entity 'MEDIATOR' named entity 'IL-10' named entity 'IMPACT' named entity 'IMMUNE SYSTEM' named entity 'IDENTIFIED' named entity 'DISCUSS' named entity 'RESPONSES' named entity 'IL-35' named entity 'SUPPRESSIVE' named entity 'mechanisms' named entity 'function' named entity 'effector' named entity 'effector' named entity 'expand' named entity 'cytokines' named entity 'organ transplantation'

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