About: Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins
Creator	Bruzzone, Roberto Hukkanen, Veijo Ianevski, Aleksandr Julkunen, Ilkka Matikainen, Sampsa Aittokallio, Tero Akimov, Yevhen Ala-Hongisto, Hanna Bugai, Andrii Bulanova, Daria Gabriel, Gülsah Guschin, Dmitry Honkimaa, Anni Kakkola, Laura Kim, Jinhee Kuivanen, Suvi Kulesskiy, Evgeny Martikainen, Miika Min, Ji-Young Nandania, Jatin Ohman, Tiina Oksenych, Valentyn Paavilainen, Henrik Pulk, Arto Sane, Famara Shim, Jungmin Turunen, Laura Vapalahti, Olli Velagapudi, Vidya Kainov, Denis Chang, So Id, † Nyman, Tuula Than, Thoa Windisch, Marc De Brabander, Jef Id, Markus Kuisma, Marika Lorey, Martina Marjomaki, Varpu Pesonen, Hanna Saarela, Jani Vähä-Koskela, Walton, Emma
Source	Medline; PMC
abstract	Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-apoptotic Bcl-2 proteins (Bcl-2i), induced the premature death of cells infected with different RNA or DNA viruses, whereas, at the same concentrations, no toxicity was observed in mock-infected cells. Moreover, these compounds limited viral replication and spread. Surprisingly, Bcl-2i also induced the premature apoptosis of cells transfected with viral RNA or plasmid DNA but not of mock-transfected cells. These results suggest that Bcl-2i sensitizes cells containing foreign RNA or DNA to apoptosis. A comparison of the toxicity, antiviral activity, and side effects of six Bcl-2i allowed us to select A-1155463 as an antiviral lead candidate. Thus, our results pave the way for the further development of Bcl-2i for the prevention and treatment of viral diseases.
has issue date	2017-09-25(xsd:dateTime)
bibo:doi	10.3390/v9100271
bibo:pmid	28946654
has license	cc-by
sha1sum (hex)	13d39b597ef6853185ff1e43a4420984a8c6416e
schema:url	https://doi.org/10.3390/v9100271
resource representing a document's title	Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins
has PubMed Central identifier	PMC5691623
has PubMed identifier	28946654
schema:publication	Viruses
resource representing a document's body	covid:13d39b597ef6853185ff1e43a4420984a8c6416e#body_text
is schema:about of	named entity 'proteins' named entity 'Thus' named entity 'activity' named entity 'remain' named entity 'apoptosis' named entity 'RNA' named entity 'toxicity' named entity 'CHEMICAL' named entity 'PROPERTIES' named entity 'ANTIVIRAL' named entity 'SPREAD' named entity 'LIMITED' named entity 'APOPTOTIC' named entity 'TREATMENT' named entity 'PUBLIC HEALTH' named entity 'VIRAL RNA' named entity 'MOCK' covid:arg/13d39b597ef6853185ff1e43a4420984a8c6416e named entity 'CONTROL' named entity 'RESULTS' named entity 'NEW' named entity 'APOPTOSIS' named entity 'CONTAINING' named entity 'BCL-2' named entity 'DNA VIRUSES' named entity 'BCL-2' named entity 'SUGGEST' named entity 'CONCENTRATIONS' named entity 'TREATMENTS' named entity 'PROTEINS' named entity 'INHIBITORS' named entity 'SIDE EFFECTS' named entity 'WAY' named entity 'PREVENTION' named entity 'COMPARISON' named entity 'PREMATURE' named entity 'PROTEINS' named entity 'OUR'

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