About: Efficient induction of cytotoxic T lymphocytes specific for severe acute respiratory syndrome (SARS)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a

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About: Efficient induction of cytotoxic T lymphocytes specific for severe acute respiratory syndrome (SARS)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Efficient induction of cytotoxic T lymphocytes specific for severe acute respiratory syndrome (SARS)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a
Creator	Taneichi, Maiko Uchida, Tetsuya Hayashi, Hidenori Kobayashi, Akiharu Kohyama, Shunsuke Matsui, Masanori Mori, Masahito Ohno, Satoshi Suda, Tatsuya Yokoyama, Shoichi
Source	Elsevier; Medline; PMC
abstract	Abstract Spike and nucleocapsid are structural proteins of severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and major targets for cytotoxic T lymphocytes (CTLs). In contrast, non-structural proteins encoded by two-thirds of viral genome are poorly characterized for cell-mediated immunity. We previously demonstrated that nucleocapsid-derived peptides chemically coupled to the surface of liposomes effectively elicited SARS-CoV-specific CTLs in mice. Here, we attempted to identify HLA-A0201-restricted CTL epitopes derived from a non-structural polyprotein 1a (pp1a) of SARS-CoV, and investigated whether liposomal peptides derived from pp1a were effective for CTL induction. Out of 30 peptides predicted on computational algorithms, nine peptides could significantly induce interferon gamma (IFN-γ)-producing CD8+ T cells in mice. These peptides were coupled to the surface of liposomes, and inoculated into mice. Six liposomal peptides effectively induced IFN-γ-producing CD8+ T cells and seven liposomal peptides including the six peptides primed CTLs showing in vivo killing activities. Further, CTLs induced by the seven liposomal peptides lysed an HLA-A0201 positive cell line expressing naturally processed, pp1a-derived peptides. Of note, one of the liposomal peptides induced high numbers of long-lasting memory CTLs. These data suggest that surface-linked liposomal peptides derived from pp1a might offer an efficient CTL-based vaccine against SARS.
has issue date	2009-11-30(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2009.09.004
bibo:pmid	19748524
has license	els-covid
sha1sum (hex)	135ee40ed73a012b4afa76f8d8a55ad41ae3a97a
schema:url	https://doi.org/10.1016/j.antiviral.2009.09.004
resource representing a document's title	Efficient induction of cytotoxic T lymphocytes specific for severe acute respiratory syndrome (SARS)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a
has PubMed Central identifier	PMC7114085
has PubMed identifier	19748524
schema:publication	Antiviral Research
resource representing a document's body	covid:135ee40ed73a012b4afa76f8d8a55ad41ae3a97a#body_text
is schema:about of	named entity 'NON-' named entity 'liposomal' named entity 'CD8' named entity 'effectively' named entity 'T cells' named entity 'Here' named entity 'efficient' named entity 'liposomal' named entity 'liposomes' named entity 'peptides' named entity 'Efficient' named entity 'STRUCTURAL POLYPROTEIN' named entity 'CYTOTOXIC' named entity 'PRODUCING' named entity 'RESTRICTED' named entity 'STRUCTURAL PROTEINS' named entity 'LONG-LASTING MEMORY' named entity 'HLA-A' named entity 'CHEMICALLY' named entity 'PEPTIDES' named entity 'NON-STRUCTURAL PROTEINS' named entity 'SARS-COV' named entity 'CORONAVIRUS' named entity 'DERIVED' named entity 'PROCESSED' named entity 'INCLUDING' named entity 'COMPUTATIONAL' named entity 'SUGGEST' named entity 'POORLY' named entity 'PP1A' named entity 'CTL' named entity 'INDUCE' named entity 'CHARACTERIZED' named entity 'OFFER' named entity 'INDUCED' named entity 'CELL LINE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'ATTEMPTED' named entity 'LIPOSOMAL' named entity 'SPECIFIC' named entity 'EFFICIENT' named entity 'PEPTIDES' named entity 'DATA' named entity 'PRIMED' named entity 'TARGETS' named entity 'NUCLEOCAPSID' named entity 'LIPOSOMES' named entity 'SPIKE' named entity 'T CELLS' named entity 'CELL-MEDIATED IMMUNITY' named entity 'SURFACE' named entity 'INDUCTION' named entity 'HIGH' named entity 'LYSED' named entity 'ASSOCIATED' named entity 'MICE' named entity 'SURFACE' named entity 'KILLING' named entity 'NUMBERS' named entity 'ELICITED' named entity 'HERE' named entity 'STRUCTURAL POLYPROTEIN' named entity 'TO IDENTIFY' named entity 'ENCODED' named entity 'THESE' named entity 'EFFECTIVE' named entity 'PREDICTED' named entity 'EFFICIENT' named entity 'IFN' named entity 'SPECIFIC' named entity 'INVESTIGATED' named entity 'ACTIVITIES'

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