About: Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis
Creator	Wang, Chih-Chien Chen, Shyi-Jou Fan, Hueng-Chuen Lo, Wen-Tsung Sytwu, Huey-Kang Wang, Yen-Ling Alex, Philip
Source	PMC
abstract	Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, and CD4(+) T cells form the core immunopathogenic cascade leading to chronic inflammation. Traditionally, Th1 cells (interferon-γ-producing CD4(+) T cells) driven by interleukin 12 (IL12) were considered to be the encephalitogenic T cells in MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Currently, Th17 cells (Il17-producing CD4(+) T cells) are considered to play a fundamental role in the immunopathogenesis of EAE. This paper highlights the growing evidence that Th17 cells play the core role in the complex adaptive immunity of EAE/MS and discusses the roles of the associated immune cells and cytokines. These constitute the modern immunological basis for the development of novel clinical and preclinical immunomodulatory therapies for MS discussed in this paper.
has issue date	2011-12-06(xsd:dateTime)
bibo:doi	10.1155/2012/970789
bibo:pmid	22203863
has license	cc-by
sha1sum (hex)	12bc88e7428c240181f181ca0358dac85ae16289
schema:url	https://doi.org/10.1155/2012/970789
resource representing a document's title	Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis
has PubMed Central identifier	PMC3235500
has PubMed identifier	22203863
schema:publication	Clin Dev Immunol
resource representing a document's body	covid:12bc88e7428c240181f181ca0358dac85ae16289#body_text
is schema:about of	named entity 'therapies' named entity 'highlights' named entity 'development' named entity 'encephalomyelitis' named entity 'experimental autoimmune encephalomyelitis' named entity 'CYTOKINES' named entity 'THERAPIES' named entity 'DEVELOPMENT' named entity 'MULTIPLE SCLEROSIS' named entity 'IMMUNOLOGICAL' named entity 'EAE' named entity 'MS.' named entity 'IMMUNOMODULATORY' named entity 'EVIDENCE' named entity 'IMMUNOMODULATION' named entity 'CD4' named entity 'GROWING' named entity 'CONSIDERED' named entity 'ADAPTIVE IMMUNITY' named entity 'STATUS' named entity 'THERAPEUTIC' named entity 'MULTIPLE SCLEROSIS' named entity 'AUTOIMMUNE DISEASE' named entity 'CLINICAL' named entity 'MODEL OF' named entity 'TH1 CELLS' named entity 'ROLE' named entity 'CORE' named entity 'CASCADE' named entity 'IMMUNE CELLS' named entity 'EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS' named entity 'BASIS' named entity 'PLAY' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'INTERLEUKIN 12' named entity 'PRECLINICAL' named entity 'COMPLEX' named entity 'ASSOCIATED' named entity 'IMMUNOPATHOGENESIS' named entity 'THESE' named entity 'TH17 CELLS' named entity 'NOVEL' named entity 'CHRONIC INFLAMMATION' named entity 'DRIVEN' named entity 'ROLES' named entity 'T CELLS' named entity 'PRODUCING' named entity 'ANIMAL MODEL' named entity 'PAPER' named entity 'CURRENTLY' named entity 'CURRENT' named entity 'STRATEGIES' named entity 'LEADING' named entity 'FORM' named entity 'immune cells' named entity 'basis' named entity 'paper' named entity 'cells' named entity 'evidence' named entity 'interleukin' named entity 'T cells' named entity 'fundamental' named entity 'Status' named entity 'Th17 cells' named entity 'Multiple sclerosis' named entity 'immune cells' named entity 'adaptive immunity' named entity 'CD4 +' named entity 'Th1 cells' named entity 'Multiple Sclerosis' named entity 'T cells' named entity 'immunomodulatory' named entity 'minocycline' named entity 'IL12' named entity 'heterogeneity'

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