About: Influence of viral load in the outcome of hospitalized patients with influenza virus infection

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About: Influence of viral load in the outcome of hospitalized patients with influenza virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Influence of viral load in the outcome of hospitalized patients with influenza virus infection
Creator	Arrieta, Estibaliz Arévalo-Cañas, Coral Ayuso, Blanca Castillo, Cristina Díaz-Pedroche, Carmen Folgueira, Dolores Hernández-Jiménez, Pilar Lalueza, Antonio Laureiro, Jaime Lumbreras, Carlos Madrid, Olaya Moral-Jiménez, Noelia Muñoz-Gallego, Irene Torres, Marta Trujillo, Hernando
source	PMC
abstract	The role of viral load in the outcome of patients requiring hospital admission due to influenza is not well established. We aim to assess if there is an association between the viral load and the outcome in hospitalized patients with a confirmed influenza virus infection. A retrospective observational study including all adult patients who were hospitalized in our center with a confirmed influenza virus infection from January to May 2016. Viral load was measured by real-time reverse-transcriptase–polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value on upper respiratory tract samples. Its value was categorized into three groups (low Ct, ≤ 20; intermediate Ct, > 20–30; and high Ct, > 30). Two hundred thirty-nine patients were included. Influenza A/H1N1pdm09 was isolated in 207 cases (86.6%). The mean Ct value was 26.69 ± 5.81. The viral load was higher in the unvaccinated group when compared with the vaccinated patients (Ct 25.17 ± 5.55 vs. 27.58 ± 4.97, p = 0.004). Only 27 patients (11.29%) presented a high viral load. Patients with a high viral load more often showed abnormal findings on chest X-ray (p = 0.015) and lymphopenia (p = 0.097). By contrast, there were no differences between the three groups (according to viral load), in associated pneumonia, respiratory failure, need for mechanical ventilation, sepsis, or in-hospital mortality. Our findings suggest that in patients admitted to the hospital with confirmed influenza virus infection (mostly A/H1N1pdm09), a high viral load is associated with a higher presence of abnormal findings on chest X-ray but not with a significant worse prognosis. In these cases, standardized quantitative PCR could be useful.
has issue date	2019-02-28(xsd:dateTime)
bibo:doi	10.1007/s10096-019-03514-1
bibo:pmid	30820840
has license	no-cc
sha1sum (hex)	12a2d60b1d2fbe08e499962d5c6c5bde0bdfbabf
schema:url	https://doi.org/10.1007/s10096-019-03514-1
resource representing a document's title	Influence of viral load in the outcome of hospitalized patients with influenza virus infection
has PubMed Central identifier	PMC7102091
has PubMed identifier	30820840
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:12a2d60b1d2fbe08e499962d5c6c5bde0bdfbabf#body_text
is schema:about of	named entity 'patients' named entity 'confirmed' named entity 'categorized' named entity 'influenza' named entity 'HOSPITALIZED PATIENTS' named entity '2886' named entity 'MEAN' named entity 'COULD BE' named entity 'QUANTITATIVE PCR' named entity 'THESE' named entity 'HIGH' named entity 'NEED FOR' named entity 'SEPSIS' named entity 'ROLE' named entity 'HOSPITAL' named entity 'FINDINGS' named entity 'REVERSE-TRANSCRIPTASE' named entity 'JANUARY' named entity 'PRESENCE OF ABNORMAL' named entity 'MORE OFTEN' named entity 'ASSOCIATION' named entity 'ESTABLISHED' named entity 'INFLUENZA A' named entity 'COMPARED' named entity 'POLYMERASE CHAIN REACTION' named entity 'PNEUMONIA' named entity 'ISOLATED' named entity 'INFLUENCE' named entity 'OUTCOME' named entity 'SIGNIFICANT' named entity 'UPPER RESPIRATORY TRACT' named entity 'BUT' named entity 'VIRUS INFECTION' named entity 'DUE TO' named entity 'CHEST X-RAY' named entity 'VIRAL LOAD' named entity 'INFLUENZA VIRUS' named entity 'ASSOCIATED' named entity 'MECHANICAL VENTILATION' named entity 'IN-HOSPITAL MORTALITY' named entity 'CONTRAST' named entity 'OBSERVATIONAL STUDY' named entity 'PCR' named entity 'CASES' named entity 'PROGNOSIS' named entity 'RETROSPECTIVE' named entity 'HOSPITAL ADMISSION' named entity 'ITS' named entity 'CENTER' named entity '004' named entity 'PRESENTED' named entity 'VALUE' named entity 'SAMPLES' named entity 'VIRAL LOAD' named entity 'ASSOCIATED WITH' named entity 'SUGGEST' named entity '28P' named entity 'VIRUS INFECTION' named entity '20%' named entity 'INFLUENZA' named entity 'INCLUDING' named entity 'VACCINATED' named entity 'THIRTY-NINE' named entity 'NOT WELL' named entity 'PATIENTS' named entity 'ASSESS' named entity 'OUR'

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