About: Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis
Creator	Tran, Dat Richardson, Susan Asner, Sandra Gharabaghi, Farhad Grasemann, Hartmut Solomon, Melinda Waters, Valerie Yau, Yvonne
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: The role of respiratory viruses in cystic fibrosis (CF) exacerbations is incompletely understood. METHODS: Cross-sectional study of CF children with a pulmonary exacerbation. Mid-turbinate swabs were tested by a direct immunofluorescent antibody assay and a multiplex PCR panel (ResPlex II v2.0, Qiagen). Resplex II was also applied to sputum or throat swab samples. Pulmonary function tests and quality of life and severity scores were recorded. Sputum cell counts, bacterial density and cytokines were measured. RESULTS: 26/43 (60.5%) subjects tested positive for at least one respiratory virus by any diagnostic method applied to any sample type. Virus-positive patients were younger (p = 0.047), more likely to be male (p = 0.029), and had higher CF clinical severity (p = 0.041) and lower quality of life (physical) scores (p = 0.023) but similar IL-8, neutrophil percentage and elastase levels. CONCLUSIONS: Compared to non-viral exacerbations, viral-related exacerbations were associated with worse severity and quality of life scores but similar pulmonary inflammation.
has issue date	2012-05-10(xsd:dateTime)
bibo:doi	10.1016/j.jcf.2012.04.006
bibo:pmid	22579414
has license	no-cc
sha1sum (hex)	117f68c79b36752fe94becf0db645b58190a401a
schema:url	https://doi.org/10.1016/j.jcf.2012.04.006
resource representing a document's title	Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis
has PubMed Central identifier	PMC7105203
has PubMed identifier	22579414
schema:publication	J Cyst Fibros
resource representing a document's body	covid:117f68c79b36752fe94becf0db645b58190a401a#body_text
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