About: The chromosomal nature of LT-II enterotoxins solved: a lambdoid prophage encodes both LT-II and one of two novel pertussis-toxin-like toxin family members in type II enterotoxigenic Escherichia coli

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About: The chromosomal nature of LT-II enterotoxins solved: a lambdoid prophage encodes both LT-II and one of two novel pertussis-toxin-like toxin family members in type II enterotoxigenic Escherichia coli Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The chromosomal nature of LT-II enterotoxins solved: a lambdoid prophage encodes both LT-II and one of two novel pertussis-toxin-like toxin family members in type II enterotoxigenic Escherichia coli
Creator	Jobling, Michael
Source	PMC
abstract	Heat-labile enterotoxins (LT) of enterotoxigenic Escherichia coli (ETEC) are structurally and functionally related to cholera toxin (CT). LT-I toxins are plasmid-encoded and flanked by IS elements, while LT-II toxins of type II ETEC are chromosomally encoded with flanking genes that appear phage related. Here, I determined the complete genomic sequence of the locus for the LT-IIa type strain SA53, and show that the LT-IIa genes are encoded by a 51 239 bp lambdoid prophage integrated at the rac locus, the site of a defective prophage in E. coli K12 strains. Of 50 LT-IIa and LT-IIc, 46 prophages also encode one member of two novel two-gene ADP-ribosyltransferase toxin families that are both related to pertussis toxin, which I named eplBA or ealAB, respectively. The eplBA and ealAB genes are syntenic with the Shiga toxin loci in their lambdoid prophages of the enteric pathogen enterohemorrhagic E. coli. These novel AB(5) toxins show pertussis-toxin-like activity on tissue culture cells, and like pertussis toxin bind to sialic acid containing glycoprotein ligands. Type II ETEC are the first mucosal pathogens known to simultaneously produce two ADP-ribosylating toxins predicted to act on and modulate activity of both stimulatory and inhibitory alpha subunits of host cell heterotrimeric G-proteins.
has issue date	2016-01-10(xsd:dateTime)
bibo:doi	10.1093/femspd/ftw001
bibo:pmid	26755534
has license	bronze-oa
sha1sum (hex)	0f8976b3ea4f96225f93d48176195bf47c177f78
schema:url	https://doi.org/10.1093/femspd/ftw001
resource representing a document's title	The chromosomal nature of LT-II enterotoxins solved: a lambdoid prophage encodes both LT-II and one of two novel pertussis-toxin-like toxin family members in type II enterotoxigenic Escherichia coli
has PubMed Central identifier	PMC4957749
has PubMed identifier	26755534
schema:publication	Pathogens and Disease
resource representing a document's body	covid:0f8976b3ea4f96225f93d48176195bf47c177f78#body_text
is schema:about of	named entity 'TOXIN' named entity 'PERTUSSIS-TOXIN' named entity 'COMPLETE' named entity 'ENTERIC' named entity 'GENOMIC SEQUENCE' named entity 'CONTAINING' named entity 'IIA' named entity 'INHIBITORY' named entity 'HETEROTRIMERIC G-PROTEINS' named entity 'LIKE' named entity 'TOXINS' named entity 'ADP-RIBOSYLTRANSFERASE' named entity 'APPEAR' named entity 'PERTUSSIS-TOXIN' named entity 'GLYCOPROTEIN' named entity 'ENCODE' named entity 'STRAINS' named entity 'TOXIN' named entity 'SUMMARY' named entity 'CELLS' named entity 'ALPHA' named entity 'ENTEROHEMORRHAGIC' named entity 'DETERMINED' named entity 'INTEGRATED' named entity 'NOVEL' named entity 'PRODUCE' named entity 'FLANKED' named entity 'FLANKING' named entity 'HERE' named entity 'PHAGE' named entity 'ENTEROTOXIN' named entity 'ADP' named entity 'TYPE STRAIN' named entity 'SIMULTANEOUSLY' named entity 'MODULATE' named entity 'ENTEROTOXINS' named entity 'TISSUE CULTURE' named entity 'E. COLI' named entity 'THEIR' named entity 'MEMBER OF' named entity 'GENES' named entity 'FAMILY MEMBERS' named entity 'NATURE' named entity 'ENTEROTOXIGENIC ESCHERICHIA COLI' named entity 'ONE OF' named entity 'PREDICTED' named entity 'GENE' named entity 'HEAT' named entity 'PATHOGENS' named entity 'PERTUSSIS TOXIN' named entity 'E. COLI K12' named entity 'MUCOSAL' named entity 'THESE' named entity 'ENCODED' named entity 'HOST CELL' named entity 'PROPHAGE' named entity 'IS ELEMENTS' named entity 'DEFECTIVE PROPHAGE' named entity 'ACT' named entity 'TYPE II' named entity 'LIKE' named entity 'NOVEL' named entity 'PROPHAGE' named entity 'CHROMOSOMAL' named entity 'PATHOGEN' named entity 'KNOWN' named entity '239' named entity 'LIGANDS' named entity 'IIC' named entity 'ENTEROTOXINS' named entity 'ACTIVITY' named entity 'LOCI' named entity 'SHIGA TOXIN' named entity 'SITE OF' named entity 'GENOME' named entity 'PROPHAGES' named entity 'FAMILIES' named entity 'SENTENCE' named entity 'CHOLERA TOXIN' named entity 'NAMED' named entity 'RELATED'

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