About: Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2
Creator	Wang, Tao Huang, Yi Sun, Wei Chen, Yin Chen, Fang Wang, Shaobo Cheng, Peng Han, Songling Li, Daixi Su, Yongping Wang, # Wang, Cheng Wang, Junping Wang, Liting Wei, Dongqing Zhao, Gaomei Zhao, Jianqi Zhao, Jinghong Zhao, Xia
Source	BioRxiv
abstract	The burgeoning epidemic caused by novel coronavirus 2019 (2019-nCoV) is currently a global concern. Angiotensin-converting enzyme-2 (ACE2) is a receptor of 2019-nCoV spike 1 protein (S1) and mediates viral entry into host cells. Despite the abundance of ACE2 in small intestine, few digestive symptoms are observed in patients infected by 2019-nCoV. Herein, we investigated the interactions between ACE2 and human defensins (HDs) specifically secreted by intestinal Paneth cells. The lectin-like HD5, rather than HD6, bound ACE2 with a high affinity of 39.3 nM and weakened the subsequent recruitment of 2019-nCoV S1. The cloak of HD5 on the ligand-binding domain of ACE2 was confirmed by molecular dynamic simulation. A remarkable dose-dependent preventive effect of HD5 on 2019-nCoV S1 binding to intestinal epithelial cells was further evidenced by in vitro experiments. Our findings unmasked the innate defense function of lectin-like intestinal defensin against 2019-nCoV, which may provide new insights into the prevention and treatment of 2019-nCoV infection.
has issue date	2020-03-31(xsd:dateTime)
bibo:doi	10.1101/2020.03.29.013490
has license	biorxiv
sha1sum (hex)	0c8ac295acf684a385eb45d0b37710affa3a9e85
schema:url	https://doi.org/10.1101/2020.03.29.013490
resource representing a document's title	Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2
schema:publication	bioRxiv
resource representing a document's body	covid:0c8ac295acf684a385eb45d0b37710affa3a9e85#body_text
is schema:about of	named entity 'Paneth cells' named entity 'patients' named entity 'molecular dynamic' named entity 'interactions' named entity 'dose-dependent' named entity 'recruitment' named entity 'defensin' named entity 'symptoms' named entity 'preventive' named entity 'ACE2' named entity 'ACE2' named entity 'intestinal' named entity 'binding' named entity '2019-nCoV' named entity '2019-nCoV' named entity 'defensins' named entity 'dose-dependent' named entity 'epidemic' named entity 'lectin' named entity '2019-nCoV' named entity 'ligand-binding domain' named entity 'protein' named entity '2019-nCoV' named entity 'HD5' named entity 'ACE2' named entity '2019-nCoV' named entity '2019-nCoV' named entity 'Caco-2' named entity 'disulfide' named entity '2019-nCoV' named entity 'DMEM' named entity 'X-ray crystal' named entity 'HD5' named entity 'HD5' named entity 'HD5' named entity 'thioredoxin' named entity 'RP-HPLC' named entity 'ACE2' named entity 'defensins' named entity 'nucleoprotein' named entity 'lysis' named entity 'Caco-2' named entity 'HD5' named entity 'Crohn's disease' named entity 'assay' named entity 'HD5' named entity 'confocal microscope' named entity 'dose-dependent manner' named entity 'inflammatory bowel diseases' named entity 'enterocytes' named entity 'human intestine' named entity 'Paneth cells' named entity 'DPP4' named entity 'protein' named entity 'enterocytes' named entity 'peptides' named entity '2.45' named entity 'HD5' named entity 'steric hindrance' named entity 'infection' named entity 'diarrhea' named entity 'constitutively expressed' named entity 'ACE2' named entity 'molecule' named entity 'RNA' named entity '2019-nCoV'

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