About: Cerebrovascular Disease in Patients with COVID-19: A Review of the Literature and Case Series

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cerebrovascular Disease in Patients with COVID-19: A Review of the Literature and Case Series
Creator	Reddy, Sujan Barreto, Andrew Bowry, Ritvij Chiu, David Gadhia, Rajan Garg, Tanu Gonzales, Nicole Imran, Rajeel Kan, Peter Kumar, Abhay Misra, Vivek Nascimento, Fábio Savitz, Sean Shah, Chintan Volpi, John
source	Medline; PMC
abstract	COVID-19 has been associated with a hypercoagulable state causing cardiovascular and neurovascular complications. To further characterize cerebrovascular disease (CVD) in COVID-19, we review the current literature of published cases and additionally report the clinical presentation, laboratory and diagnostic testing results of 12 cases with COVID-19 infection and concurrent CVD from two academic medical centers in Houston, TX, USA, between March 1 and May 10, 2020. To date, there are 12 case studies reporting 47 cases of CVD in COVID-19. However, only 4 small case series have described the clinical and laboratory findings in patients with COVID-19 and concurrent stroke. Viral neurotropism, endothelial dysfunction, coagulopathy and inflammation are plausible proposed mechanisms of CVD in COVID-19 patients. In our case series of 12 patients, 10 patients had an ischemic stroke, of which 1 suffered hemorrhagic transformation and two had intracerebral hemorrhage. Etiology was determined to be embolic without a clear cause identified in 6 ischemic stroke patients, while the remaining had an identifiable source of stroke. The majority of the patients had elevated inflammatory markers such as D-dimer and interleukin-6. In patients with embolic stroke of unclear etiology, COVID-19 may have played a direct or indirect role in the processes that eventually led to the strokes while in the remaining cases, it is unclear if infection contributed partially or was an incidental finding.
has issue date	2020-06-11(xsd:dateTime)
bibo:doi	10.1159/000508958
bibo:pmid	32647526
has license	cc-by-nc
sha1sum (hex)	0c2d75788a3eefab4c24fdfa89ad77b721c818ea
schema:url	https://doi.org/10.1159/000508958
resource representing a document's title	Cerebrovascular Disease in Patients with COVID-19: A Review of the Literature and Case Series
has PubMed Central identifier	PMC7325208
has PubMed identifier	32647526
schema:publication	Case Rep Neurol
resource representing a document's body	covid:0c2d75788a3eefab4c24fdfa89ad77b721c818ea#body_text
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