About: Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo

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About: Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo
Creator	Akoua-Koffi, Chantal Michaelis, Martin Klempa, Boris Auste, Brita Karhemere, Stomy Muyembe-Tamfum, Jean-Jacques Schubert, Grit Krüger, Detlev Leendertz, Fabian Leendertz, Siv Witkowski, Peter
source	Medline; PMC
abstract	Hantaviruses are members of the Bunyaviridae family carried by small mammals and causing human hemorrhagic fevers worldwide. In Western Africa, where a variety of hemorrhagic fever viruses occurs, indigenous hantaviruses have been molecularly found in animal reservoirs such as rodents, shrews, and bats since 2006. To investigate the human contact to hantaviruses carried by these hosts and to assess the public health relevance of hantaviruses for humans living in the tropical rainforest regions of Western and Central Africa, we performed a cross-sectional seroprevalence study in the region of Taï National Park in Côte d’Ivoire and the Bandundu region near the Salonga National Park in the Democratic Republic (DR) of Congo. Serum samples were initially screened with enzyme-linked immunosorbent assays using nucleoproteins of several hantaviruses as diagnostic antigens. Positive results were confirmed by Western blotting and immunofluorescence testing. Seroprevalence rates of 3.9% (27/687) and 2.4% (7/295), respectively, were found in the investigated regions in Côte d’Ivoire and the DR Congo. In Côte d’Ivoire, this value was significantly higher than the seroprevalence rates previously reported from the neighboring country Guinea as well as from South Africa. Our study indicates an exposure of humans to hantaviruses in West and Central African tropical rainforest areas. In order to pinpoint the possible existence and frequency of clinical disease caused by hantaviruses in this region of the world, systematic investigations of patients with fever and renal or respiratory symptoms are required.
has issue date	2015-05-21(xsd:dateTime)
bibo:doi	10.3389/fmicb.2015.00518
bibo:pmid	26052326
has license	cc-by
sha1sum (hex)	0bcbf352d92ce90e1c2595fb458ded32b45002a0
schema:url	https://doi.org/10.3389/fmicb.2015.00518
resource representing a document's title	Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo
has PubMed Central identifier	PMC4439549
has PubMed identifier	26052326
schema:publication	Front Microbiol
resource representing a document's body	covid:0bcbf352d92ce90e1c2595fb458ded32b45002a0#body_text
is schema:about of	named entity 'TROPICAL RAINFORESTS' named entity 'INDICATING' named entity 'Bandundu' named entity 'fever' named entity 'caused' named entity 'public health' named entity 'Central Africa' named entity 'patients' named entity 'Human' named entity 'SEROPREVALENCE' named entity 'FREQUENCY' named entity 'WEST' named entity 'SHREWS' named entity 'CONGO' named entity 'RESERVOIRS' named entity 'SMALL' named entity 'VARIETY' named entity 'GUINEA' named entity 'HAVE' named entity 'HANTAVIRUSES' named entity 'DR CONGO' named entity 'IMMUNOFLUORESCENCE' named entity 'REGIONS' named entity 'DIAGNOSTIC ANTIGENS' named entity 'SAMPLES' named entity 'SALONGA NATIONAL PARK' named entity 'HUMAN' named entity 'MEMBERS' named entity 'DISEASE' named entity 'SOUTH AFRICA' named entity '3.9' named entity 'AREAS' named entity 'RATES' named entity 'SEROPREVALENCE' named entity 'PINPOINT' named entity 'RELEVANCE' named entity 'ANIMAL' named entity 'REPUBLIC' named entity 'HEMORRHAGIC FEVER VIRUSES' named entity 'USING' named entity 'VALUE' named entity 'INVESTIGATIONS' named entity 'REQUIRED' named entity 'NEIGHBORING' named entity 'HOSTS' named entity 'POSSIBLE' named entity 'INVESTIGATED' named entity 'RENAL' named entity 'SERUM' named entity 'MAMMALS' named entity 'CAUSING' named entity 'FAMILY' named entity 'EXPOSURE' named entity 'CENTRAL AFRICAN' named entity 'WESTERN AFRICA' named entity 'STUDY' named entity 'REPORTED' named entity 'ENZYME-LINKED IMMUNOSORBENT ASSAYS' named entity 'BUNYAVIRIDAE' named entity 'NATIONAL PARK' named entity 'REPUBLIC OF CONGO' named entity 'INDIGENOUS' named entity 'PATIENTS' named entity 'WHERE' named entity 'HIGHER' named entity 'WORLD' named entity 'CROSS-SECTIONAL' named entity '287' named entity 'CENTRAL AFRICA' named entity 'HANTAVIRUS INFECTIONS' named entity 'REGION'

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