About: Expression of miR-155 associated with Toll-like receptors 3, 7, and 9 transcription in the olfactory bulbs of cattle naturally infected with BHV5

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About: Expression of miR-155 associated with Toll-like receptors 3, 7, and 9 transcription in the olfactory bulbs of cattle naturally infected with BHV5 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Expression of miR-155 associated with Toll-like receptors 3, 7, and 9 transcription in the olfactory bulbs of cattle naturally infected with BHV5
Creator	Gameiro, Roberto Cardoso, Tereza Da Silva, Sergio Dielson, & Flores, Eduardo Oliveira, Bruna Vieira, Flavia Vieira, S
Source	Medline; PMC
abstract	Bovine herpesvirus 5 (BHV5) infection of young cattle is frequently associated with fatal neurological disease and, as such, represents an attractive model for studying the pathogenesis of viral-induced meningoencephalitis. Following replication in the nasal mucosa, BHV5 invades the central nervous system (CNS) mainly through the olfactory pathway. The innate immune response triggered by the host face to virus replication through the olfactory route is poorly understood. Recently, an upregulation of conserved pathogen-associated molecular pattern, as Toll-like receptors (TLRs), has been demonstrated in the CNS of BHV5 experimentally infected cows. A new perspective to understand host-pathogen interactions has emerged elucidating microRNAs (miRNAs) network that interact with innate immune response during neurotropic viral infections. In this study, we demonstrated a link between the expression of TLRs 3, 7, and 9 and miR-155 transcription in the olfactory bulbs (OB) of 16 cows suffering from acute BHV5-induced neurological disease. The OBs were analyzed for viral antigens and genome, miR-155 and TLR 3, 7, and 9 expression considering three major regions: olfactory receptor neurons (ORNs), glomerular layer (GL), and mitral cell layer (ML). BHV5 antigens and viral genomes, corresponding to glycol-C gene, were detected in all OBs regions by fluorescent antibody assay (FA) and PCR, respectively. TLR 3, 7, and 9 transcripts were upregulated in ORNs and ML, yet only ORN layers revealed a positive correlation between TLR3 and miR-155 transcription. In ML, miR-155 correlated positively with all TLRs studied. Herein, our results evidence miR-155 transcription in BHV5 infected OB tissue associated to TLRs expression specifically ORNs which may be a new window for further studies.
has issue date	2017-08-22(xsd:dateTime)
bibo:doi	10.1007/s13365-017-0564-6
bibo:pmid	28831740
has license	no-cc
sha1sum (hex)	0aa0d50125fe98feab1d98aba6760b14f4fe3927
schema:url	https://doi.org/10.1007/s13365-017-0564-6
resource representing a document's title	Expression of miR-155 associated with Toll-like receptors 3, 7, and 9 transcription in the olfactory bulbs of cattle naturally infected with BHV5
has PubMed Central identifier	PMC7095048
has PubMed identifier	28831740
schema:publication	J Neurovirol
resource representing a document's body	covid:0aa0d50125fe98feab1d98aba6760b14f4fe3927#body_text
is schema:about of	named entity 'EXPRESSION' named entity 'transcription' named entity 'study' named entity 'detected' named entity 'herpesvirus' named entity 'interact' named entity 'olfactory' named entity 'innate immune response' named entity 'invades' named entity 'tissue' named entity 'infected' named entity 'upregulation' named entity 'triggered' named entity 'miR-155' named entity 'CATTLE' named entity 'BOVINE HERPESVIRUS 5' named entity 'TRANSCRIPTS' named entity 'NETWORK' named entity 'MICRORNAS' named entity 'NEUROLOGICAL DISEASE' named entity 'MAJOR' named entity 'PATHOGENESIS' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'NEW' named entity 'WINDOW' named entity 'STUDIES' named entity 'TRANSCRIPTION' named entity 'OLFACTORY RECEPTOR NEURONS' named entity 'PATTERN' named entity 'INDUCED' named entity 'STUDY' named entity 'CORRELATED' named entity 'VIRUS REPLICATION' named entity 'GENOMES' named entity 'MOLECULAR' named entity 'TISSUE' named entity 'UNDERSTOOD' named entity 'COWS' named entity 'OLFACTORY PATHWAY' named entity 'PCR' named entity 'INFECTED' named entity 'GENOME' named entity 'VIRAL ANTIGENS' named entity 'ROUTE' named entity 'MIR-155' named entity 'INFECTED' named entity 'TRIGGERED BY' named entity 'NEUROTROPIC' named entity 'INTERACT' named entity 'CNS' named entity 'OUR' named entity 'TLR' covid:arg/0aa0d50125fe98feab1d98aba6760b14f4fe3927 named entity 'TOLL-LIKE RECEPTORS' named entity 'RECENTLY' named entity 'MODEL' named entity 'NASAL MUCOSA' named entity 'GLYCOL' named entity 'UPREGULATED' named entity 'EXPRESSION' named entity 'FACE' named entity 'REVEALED' named entity 'INTERACTIONS' named entity 'UPREGULATION' named entity 'OBS' named entity 'CONSERVED' named entity 'FOLLOWING' named entity 'OLFACTORY BULBS' named entity 'FLUORESCENT ANTIBODY ASSAY' named entity 'INFECTION' named entity 'CATTLE' named entity 'TOLL-LIKE RECEPTORS' named entity 'CORRELATION' named entity 'ASSOCIATED'

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