About: An ancient deletion in the ABO gene affects the composition of the porcine microbiome by altering intestinal N-acetyl-galactosamine concentrations

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About: An ancient deletion in the ABO gene affects the composition of the porcine microbiome by altering intestinal N-acetyl-galactosamine concentrations Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An ancient deletion in the ABO gene affects the composition of the porcine microbiome by altering intestinal N-acetyl-galactosamine concentrations
Creator	Yang, Hui Liu, Min Jiang, Hui Fu, Hao Chen, Zhe Yang, Bin Liu, Qin Zhang, Yifeng Gao, Jun Ai, Huashui Charlier, Chen, Congying Coppieters, Wouter Fang, Shaoming Gong, Huanfa He, Maozhang Huang, Lusheng Huang, Xiaochang Huang, Yizhong Ke, Shanlin Ma, Junwu Shagam, Lev Tong, Xinkai Wu, Jinyuan Wu, Zhongzi Xiong, Xinwei Zhang, Zhiyan Zhou, Yunyan
Source	BioRxiv
abstract	We have generated a large heterogenous stock population by intercrossing eight divergent pig breeds for multiple generations. We have analyzed the composition of the intestinal microbiota at different ages and anatomical locations in > 1,000 6th- and 7th- generation animals. We show that, under conditions of exacerbated genetic yet controlled environmental variability, microbiota composition and abundance of specific taxa (including Christensenellaceae) are heritable in this monogastric omnivore. We fine-map a QTL with major effect on the abundance of Erysipelotrichaceae to chromosome 1q and show that it is caused by a common 2.3-Kb deletion inactivating the ABO acetyl-galactosaminyl-transferase gene. We show that this deletion is a trans-species polymorphism that is ≥3.5 million years old and under balancing selection. We demonstrate that it acts by decreasing the concentrations of N-acetyl-galactosamine in the cecum thereby reducing the abundance of Erysipelotrichaceae strains that have the capacity to import and catabolize N-acetyl-galactosamine.
has issue date	2020-07-16(xsd:dateTime)
bibo:doi	10.1101/2020.07.16.206219
has license	biorxiv
sha1sum (hex)	0a70327be3362a6b54a02c5552a570d6f80f396f
schema:url	https://doi.org/10.1101/2020.07.16.206219
resource representing a document's title	An ancient deletion in the ABO gene affects the composition of the porcine microbiome by altering intestinal N-acetyl-galactosamine concentrations
schema:publication	bioRxiv
resource representing a document's body	covid:0a70327be3362a6b54a02c5552a570d6f80f396f#body_text
is schema:about of	named entity 'generation' named entity 'locations' named entity 'controlled' named entity 'composition' named entity 'microbiome' named entity 'ages' named entity 'large' named entity 'locus' named entity 'microbiota' named entity 'N-acetyl-galactosamine' named entity 'microbiome' named entity 'taxa' named entity 'regulon' named entity 'taxa' named entity 'feces' named entity 'phyla' named entity 'cecal' named entity 'host-pathogen interactions' named entity 'chromosome' named entity 'genome' named entity 'QTL' named entity 'genome-wide' named entity 'GalNAc' named entity 'GalNAc' named entity 'microbiota' named entity 'genotype' named entity 'intestinal content' named entity 'carbon' named entity 'entire genome' named entity 'feces' named entity 'Erysipelotrichaceae' named entity 'Erysipelotrichaceae' named entity 'cecal' named entity 'feces' named entity 'heritability' named entity 'randomly selected' named entity 'ileal' named entity 'monosaccharides' named entity 'genomes' named entity 'genome-wide' named entity 'taxa' named entity 'actinobacteria' named entity 'porcine' named entity 'Firmicutes' named entity 'glycosylated' named entity 'genomes' named entity 'operon' named entity 'feces' named entity '16S rRNA' named entity 'GalNAc' named entity 'genus' named entity 'ABO blood group' named entity 'principal components' named entity 'porcine' named entity 'statistical models' named entity 'regulon' named entity 'taxon'

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