About: Time-series plasma cell-free DNA analysis reveals disease severity of COVID-19 patients

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About: Time-series plasma cell-free DNA analysis reveals disease severity of COVID-19 patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Time-series plasma cell-free DNA analysis reveals disease severity of COVID-19 patients
Creator	Jin, Xin Wang, Jian Li, Hui Zhang, Chen Liu, Ming »more»
source	MedRxiv
abstract	Symptoms of coronavirus disease 2019 (COVID-19) range from asymptomatic to severe pneumonia and death. Detection of individuals at high risk for critical condition is crucial for control of the disease. Herein, for the first time, we profiled and analyzed plasma cell-free DNA (cfDNA) of mild and severe COVID-19 patients. We found that in comparison between mild and severe COVID-19 patients, Interleukin-37 signaling was one of the most relevant pathways; top significantly altered genes included POTEH, FAM27C, SPATA48, which were mostly expressed in prostate and testis; adrenal glands, small intestines and liver were tissues presenting most differentially expressed genes. Our data thus revealed potential tissue involvement, provided insights into mechanism on COVID-19 progression, and highlighted utility of cfDNA as a noninvasive biomarker for disease severity inspections.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1101/2020.06.08.20124305
has license	medrxiv
sha1sum (hex)	0a256d2a62ed04438adbb9f406fd7522b80f8c5f
schema:url	https://doi.org/10.1101/2020.06.08.20124305
resource representing a document's title	Time-series plasma cell-free DNA analysis reveals disease severity of COVID-19 patients
resource representing a document's body	covid:0a256d2a62ed04438adbb9f406fd7522b80f8c5f#body_text
is schema:about of	named entity 'plasma' named entity 'fungi' named entity 'dendrogram' named entity 'squalene' named entity 'Gene set enrichment analysis' »more»

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