About: Anti-endotoxin Properties of Polymyxin B-immobilized Fibers

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Anti-endotoxin Properties of Polymyxin B-immobilized Fibers
Creator	Endo, Yoshihiro Shimizu, Tomoharu Shoji, Hisataka Tani, Masaji Tani, Tohru
source	PMC
abstract	Polymyxin B is an antibiotic that shows strong bactericidal activity against Gram-negative bacteria, by binding to and inactivating endotoxin. Systemic administration of polymyxin B in humans is restricted because of its nephrotoxicity and neurotoxicity, and this compound was therefore considered a strong candidate ligand for the extracorporeal selective adsorption of circulating endotoxin in the blood. Toraymyxin® is a direct hemoperfusion column that uses polymyxin B attached to an insoluble carrier to bind endotoxin in the blood. In 1994, the Japanese National Health Insurance system approved the use of Toraymyxin for the treatment of endotoxemia and septic shock. In this chapter, we will review the development, clinical use, and efficacy of Toraymyxin, examine the structure of the Toraymyxin column, and comment on the current position of Toraymyxin in the treatment of severe sepsis and septic shock. We will also highlight some potential new applications of Toraymyxin for pulmonary diseases.
has issue date	2019-07-31(xsd:dateTime)
bibo:doi	10.1007/978-3-030-16373-0_19
bibo:pmid	31364085
has license	no-cc
sha1sum (hex)	09bc0e3eaf8bdb12cde63e27d79181020f673c3f
schema:url	https://doi.org/10.1007/978-3-030-16373-0_19
resource representing a document's title	Anti-endotoxin Properties of Polymyxin B-immobilized Fibers
has PubMed Central identifier	PMC7123644
has PubMed identifier	31364085
schema:publication	Polymyxin Antibiotics: From Laboratory Bench to Bedside
resource representing a document's body	covid:09bc0e3eaf8bdb12cde63e27d79181020f673c3f#body_text
is schema:about of	named entity 'endotoxin' named entity 'TORAYMYXIN' named entity 'BACTERICIDAL ACTIVITY' named entity 'ENDOTOXEMIA' named entity 'COLUMN' named entity 'antibiotic' named entity 'adsorption' named entity 'ligand' named entity 'Polymyxin B' named entity 'endotoxin' named entity 'circulating' named entity 'bactericidal' named entity 'strong' named entity 'Fibers' named entity 'Systemic administration' named entity 'septic shock' named entity 'endotoxin' named entity 'endotoxin' named entity 'expression levels' named entity 'polymyxin' named entity 'endotoxin' named entity 'sepsis' named entity 'Plasma' named entity 'peritonitis' named entity 'polymyxin' named entity 'polymyxin' named entity 'control group' named entity 'intermolecular' named entity 'LAL' named entity 'fraction of inspired oxygen' named entity 'heparin' named entity 'endotoxin' named entity 'extracorporeal' named entity 'hemoperfusion' named entity 'infection' named entity 'hemoperfusion' named entity 'polymer' named entity 'LAL' named entity 'anandamide' named entity 'medical therapy' named entity 'LAL' named entity 'IPF' named entity 'nafamostat' named entity 'endotoxemia' named entity 'Vietnam' named entity 'hemoperfusion' named entity 'immune cells' named entity 'mortality rate' named entity 'toxic symptoms' named entity 'pulmonary medicine' named entity 'RCT' named entity 'HLA-DR' named entity 'monomer' named entity 'H5N1' named entity 'monocytes' named entity 'endotoxin' named entity 'adsorbed' named entity 'saline' named entity 'sepsis' named entity 'leukocyte' named entity 'conjugated' named entity 'endotoxin' named entity 'Thailand' named entity 'Japan' named entity 'endotoxin' named entity 'transcription factor' named entity 'hemodynamic' named entity 'meta-analysis' named entity 'micellar structure' named entity 'endotoxin' named entity 'endotoxin' named entity 'Toraymyxin' named entity 'Chronic Health' named entity 'half-lives' named entity 'polymyxin' named entity 'endotoxin' named entity 'Pseudomonas aeruginosa'

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