About: Secretory Leukocyte Protease Inhibitor Binds to Annexin II, a Cofactor for Macrophage HIV-1 Infection

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About: Secretory Leukocyte Protease Inhibitor Binds to Annexin II, a Cofactor for Macrophage HIV-1 Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Secretory Leukocyte Protease Inhibitor Binds to Annexin II, a Cofactor for Macrophage HIV-1 Infection
Creator	Greenwell-Wild, Teresa Hardegen, Neil Jin, Wenwen Lei, Kejian Ma, Ge Swisher, Jennifer Wahl, Sharon Wild, Carl
Source	Medline; PMC
abstract	The distribution of secretory leukocyte protease inhibitor (SLPI) at entry portals indicates its involvement in defending the host from pathogens, consistent with the ability of SLPI to inhibit human immunodeficiency virus (HIV)-1 infection by an unknown mechanism. We now demonstrate that SLPI binds to the membrane of human macrophages through the phospholipid-binding protein, annexin II. Based on the recent identification of human cell membrane phosphatidylserine (PS) in the outer coat of HIV-1, we define a novel role for annexin II, a PS-binding moiety, as a cellular cofactor supporting macrophage HIV-1 infection. Moreover, this HIV-1 PS interaction with annexin II can be disrupted by SLPI or other annexin II–specific inhibitors. The PS–annexin II connection may represent a new target to prevent HIV-1 infection.
has issue date	2004-11-15(xsd:dateTime)
bibo:doi	10.1084/jem.20041115
bibo:pmid	15545357
has license	cc-by-nc-sa
sha1sum (hex)	0994b9aa851f17dc1c6af309973fe189118ab6c5
schema:url	https://doi.org/10.1084/jem.20041115
resource representing a document's title	Secretory Leukocyte Protease Inhibitor Binds to Annexin II, a Cofactor for Macrophage HIV-1 Infection
has PubMed Central identifier	PMC2211913
has PubMed identifier	15545357
schema:publication	J Exp Med
resource representing a document's body	covid:0994b9aa851f17dc1c6af309973fe189118ab6c5#body_text
is schema:about of	named entity 'MECHANISM' named entity 'REPRESENT' named entity 'MOIETY' named entity 'TO PREVENT' named entity 'PHOSPHATIDYLSERINE' named entity 'MACROPHAGES' named entity 'ABILITY' named entity 'SUPPORTING' named entity 'PATHOGENS' named entity 'NEW TARGET' named entity 'HIV-1 INFECTION' named entity 'DISTRIBUTION' named entity 'HIV-1' named entity 'RECENT' named entity 'MEMBRANE' named entity 'DISRUPTED' named entity 'BASED' named entity 'membrane' named entity 'UNKNOWN' named entity 'INTERACTION' named entity 'HIV-1 INFECTION' named entity 'ITS' named entity 'NOVEL' named entity 'SECRETORY LEUKOCYTE PROTEASE INHIBITOR' named entity 'HUMAN CELL' named entity 'ANNEXIN II' named entity 'BINDS' named entity 'MACROPHAGE' named entity 'SECRETORY LEUKOCYTE PROTEASE INHIBITOR' named entity 'MACROPHAGE' named entity 'INFECTION' named entity 'SLPI' named entity 'SPECIFIC' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'CELL MEMBRANE' named entity 'INHIBITORS' named entity 'HOST' named entity 'BINDS' named entity 'PROTEIN' named entity 'CONNECTION' named entity 'HUMAN' named entity 'TO INHIBIT' named entity 'COFACTOR' named entity 'COFACTOR' named entity 'INVOLVEMENT' named entity 'ROLE' named entity 'BINDING' named entity 'ENTRY' named entity 'CELLULAR' named entity 'OUTER' named entity 'PORTALS' named entity 'COAT' named entity 'ANNEXIN II' named entity 'IDENTIFICATION' named entity 'CONSISTENT WITH' covid:arg/0994b9aa851f17dc1c6af309973fe189118ab6c5 named entity 'annexin II' named entity 'leukocyte' named entity 'connection' named entity 'target' named entity 'inhibit' named entity 'staining' named entity 'HIV-1' named entity 'p24' named entity 'macrophages' named entity 'supernatants' named entity 'PerkinElmer' named entity 'goat' named entity 'HIV-1' named entity 'Nested PCR' named entity 'HIV-1' named entity 'distribution' named entity 'Protease' named entity 'Leukocyte'

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