About: Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia

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About: Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia
Creator	Xiong, Yong Deng, Liping Ma, Zhiyong Mo, Pingzheng Song, Shihui Wang, Fan Zhang, Yongxi Zhao, Qiu Wang, Haizhou Nie, Jiayan
Source	Medline; PMC
abstract	BACKGROUND: In December 2019, novel coronavirus (SARS-CoV-2) pneumonia (COVID-19) was reported in Wuhan and has since rapidly spread throughout China. We aimed to clarify the characteristics and clinical significance of peripheral lymphocyte subset alteration in COVID-19. METHODS: The levels of peripheral lymphocyte subsets were measured by flow cytometry in 60 hospitalized COVID-19 patients before and after treatment, and their association with clinical characteristics and treatment efficacy was analyzed. RESULTS: Total lymphocytes, CD4(+) T cells, CD8(+) T cells, B cells, and natural killer (NK) cells decreased in COVID-19 patients, and severe cases had a lower level than mild cases. The subsets showed a significant association with inflammatory status in COVID-19, especially CD8(+) T cells and CD4(+)/CD8(+) ratio. After treatment, 37 patients (67%) showed clinical response, with an increase in CD8(+) T cells and B cells. No significant change in any subset was detected in nonresponsive cases. In multivariate analysis, posttreatment decrease in CD8(+) T cells and B cells and increase in CD4(+)/CD8(+) ratio were indicated as independent predictors of poor efficacy. CONCLUSIONS: Peripheral lymphocyte subset alteration was associated with clinical characteristics and treatment efficacy of COVID-19. CD8(+) T cells tended to be an independent predictor for COVID-19 severity and treatment efficacy.
has issue date	2020-03-30(xsd:dateTime)
bibo:doi	10.1093/infdis/jiaa150
bibo:pmid	32227123
has license	no-cc
sha1sum (hex)	0741aa85783fe2bf7daeb61bde1c1aa67feaaf50
schema:url	https://doi.org/10.1093/infdis/jiaa150
resource representing a document's title	Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia
has PubMed Central identifier	PMC7184346
has PubMed identifier	32227123
schema:publication	J Infect Dis
resource representing a document's body	covid:0741aa85783fe2bf7daeb61bde1c1aa67feaaf50#body_text
is schema:about of	named entity 'pneumonia' named entity 'Alteration' named entity 'Subset' named entity 'CLARIFY' named entity 'CLINICAL SIGNIFICANCE' covid:arg/0741aa85783fe2bf7daeb61bde1c1aa67feaaf50 named entity 'subset' named entity 'rapidly' named entity 'peripheral' named entity 'Background' named entity 'Pneumonia' named entity 'clinical significance' named entity 'pneumonia' named entity 'subset' named entity 'lymphocyte' named entity 'COVID-19' named entity 'anti-inflammatory' named entity 'CD4 +' named entity 'ESR' named entity 'chemokines' named entity 'antiviral treatment' named entity 'CRP' named entity 'MERS' named entity 'comorbidities' named entity 'oxygen' named entity 'CD8 +' named entity 'lymphocyte subsets' named entity 'COVID-19' named entity 'Lymphocytes' named entity 'inhalation' named entity 'ROC' named entity 'Hypertension' named entity 'infectious disease' named entity 'CD8 +' named entity 'CD3' named entity 'negatively correlated' named entity 'MERS' named entity 'significant difference' named entity 'CD8 +' named entity 'T-cell' named entity 'CD4 +' named entity 'antiviral' named entity 'SARS-CoV-2' named entity 'oxygen' named entity 'IL-6' named entity 'COVID-19' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'partial pressure of arterial oxygen' named entity 'T-cell' named entity 'chest CT' named entity 'cytokine storm' named entity 'SARS' named entity 'NK cells' named entity 'genome-wide' named entity 'positively correlated' named entity 'lymphocyte subsets' named entity 'CD16' named entity 'flow cytometry' named entity 'CD4 +' named entity 'CD8 +' named entity 'CD8 +' named entity 'biomarkers' named entity 'IL-6' named entity 'CD8 +' named entity 'RNA' named entity 'CD3' named entity 'SARS-CoV-2' named entity 'lymphocytes' named entity 'CD56' named entity 'COVID-19' named entity 'antiviral'

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