About: RSV and its propensity for causing bronchiolitis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	RSV and its propensity for causing bronchiolitis
Creator	Pickles, Raymond Devincenzo, John
Source	Medline; PMC
abstract	Infants and young children with acute onset of wheezing and reduced respiratory airflows are often diagnosed with obstruction and inflammation of the small bronchiolar airways, i.e., bronchiolitis. The most common eitological agents causing bronchiolitis in young children are the respiratory viruses and of the commonly encountered respiratory viruses, Respiratory Syncytial Virus (RSV) has a propensity for causing bronchiolitis. Indeed, RSV bronchiolitis remains the major reason why previously healthy infants are admitted to hospital. Why RSV infection is such a predominant cause of bronchiolitis is the subject of this review. By reviewing the available histopathology of RSV bronchiolitis both in humans and relevant animal models we identify hallmark features of RSV infection of the distal airways and focus attention on the consequences of columnar cell cytopathology occurring in the bronchioles, which directly impacts the development of bronchiolar obstruction, inflammation and disease.
has issue date	2014-12-11(xsd:dateTime)
bibo:doi	10.1002/path.4462
bibo:pmid	25302625
has license	bronze-oa
sha1sum (hex)	03c3f8b980a0b0bc64bed96390f01c25e4a98a32
schema:url	https://doi.org/10.1002/path.4462
resource representing a document's title	RSV and its propensity for causing bronchiolitis
has PubMed Central identifier	PMC5638117
has PubMed identifier	25302625
schema:publication	The Journal of Pathology
resource representing a document's body	covid:03c3f8b980a0b0bc64bed96390f01c25e4a98a32#body_text
is schema:about of	named entity 'cell' named entity 'causing' named entity 'caused' named entity 'Respiratory syncytial virus' named entity 'AIRWAYS' named entity 'BRONCHIOLAR' named entity 'INFLAMMATION' named entity 'COLUMNAR CELL' named entity 'CAUSING' named entity 'RESPIRATORY VIRUSES' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'commonly' named entity 'RSV infection' named entity 'animal models' named entity 'columnar' named entity 'respiratory' named entity 'subject' named entity 'viruses' named entity 'infected' named entity 'animal models' named entity 'bronchiolitis' named entity 'RSV' named entity 'Respiratory syncytial virus' named entity 'viruses' named entity 'hallmark' named entity 'airway obstruction' named entity 'infection' named entity 'sequelae' named entity 'bronchiolar' named entity 'lumenal' named entity 'RSV infection' named entity 'hypoxaemia' named entity 'cilia' named entity 'bronchoscopic' named entity 'RSV infection' named entity 'virus' named entity 'autopsy' named entity 'nasal mucus' named entity 'anti-inflammatory' named entity 'epithelial cells' named entity 'RSV' named entity 'bacterial colonization' named entity 'RSV' named entity 'syncytia' named entity 'RSV' named entity 'experimental models' named entity 'ciliated cells' named entity 'bronchioles' named entity 'influenza virus' named entity 'RSV' named entity 'distal' named entity 'infection' named entity 'mortality rates' named entity 'post-mortem' named entity 'mucus' named entity 'RSV' named entity 'epithelial cells' named entity 'pathogens' named entity 'influenza viruses' named entity 'sloughing' named entity 'ciliated' named entity 'RSV' named entity 'bronchiolitis' named entity 'infection' named entity 'end-stage' named entity 'bovine' named entity 'mucociliary' named entity 'viral pathways' named entity 'positive-pressure' named entity 'RSV infection' named entity 'biopsies' named entity 'distal' named entity 'RSV infection' named entity 'histopathology' named entity 'viruses' named entity 'mucus' named entity 'morphology' named entity 'bronchiolar' named entity 'viruses' named entity 'murine'

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