About: Secondary pneumonia in critically ill ventilated patients with COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Secondary pneumonia in critically ill ventilated patients with COVID-19
Creator	Parmar, Surendra Baker, Stephen Morris, Andrew Dougan, Gordon Curran, Martin Brown, Nicholas Forrest, Sally Khokhar, Fahad Maes, Mailis Pereira-Dias, Joana Scott, Josefin Sridhar, Sushmita Conway-Morris, Andrew Cuchet-Lourenço, Delphine Higginson, Ellen Lux, Janine Mahroof, Razeen Navapurkar, Vilas Ravenhill, Benjamin Sharma-Hajela, Sapna Solderholm, Amelia
Source	MedRxiv
abstract	Background Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients require admission to an intensive care unit (ICU) for invasive artificial ventilation and are at significant risk of developing a secondary, ventilator-associated pneumonia (VAP). Objectives To study the incidence of VAP, as well as differences in secondary infections, and bacterial lung microbiome composition of ventilated COVID-19 and non-COVID-19 patients. Methods In this prospective observational study, we compared the incidence of VAP and secondary infections using a combination of a TaqMan multi-pathogen array and microbial culture. In addition, we determined the lung microbime composition using 16S RNA analyisis. The study involved eighteen COVID-19 and seven non-COVID-19 patients receiving invasive ventilation in three ICUs located in a single University teaching hospital between April 13th 2020 and May 7th 2020. Results We observed a higher percentage of confirmed VAP in COVID-19 patients. However, there was no statistical difference in the detected organisms or pulmonary microbiome when compared to non-COVID-19 patients. Conclusion COVID-19 makes people more susceptible to developing VAP, partly but not entirely due to the increased duration of ventilation. The pulmonary dysbiosis caused by COVID-19, and the array of secondary infections observed are similar to that seen in critically ill patients ventilated for other reasons.
has issue date	2020-06-28(xsd:dateTime)
bibo:doi	10.1101/2020.06.26.20139873
has license	medrxiv
sha1sum (hex)	038c26ffc03221c90df13408f1591c0bfa09f23c
schema:url	https://doi.org/10.1101/2020.06.26.20139873
resource representing a document's title	Secondary pneumonia in critically ill ventilated patients with COVID-19
resource representing a document's body	covid:038c26ffc03221c90df13408f1591c0bfa09f23c#body_text
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