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About:
Picornavirus etiology of acute infections among hospitalized infants()
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An Entity of Type :
schema:ScholarlyArticle
, within Data Space :
covidontheweb.inria.fr
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document(s)
Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Picornavirus etiology of acute infections among hospitalized infants()
Creator
Tong, Suxiang
Watt, James
Watson, John
Messacar, Kevin
Abedi, Glen
Queen, Krista
Rogers, Shannon
Gerber, Susan
Dominguez, Samuel
Nix, W
Oberste, M
Luong, William
Rothrock, Gretchen
Source
Elsevier; Medline; PMC
abstract
BACKGROUND: Enteroviruses (EV) and parechoviruses (PeV) are ubiquitous viruses that cause a range of illness, including acute illness in children aged <1 year. OBJECTIVES: We describe EV and PeV infections among children from 2 US study sites aged <1 year and hospitalized with acute infections. For EV- and PeV-negative case-patients, we explored other viral etiologies. METHODS: Participants were aged <1 year, hospitalized during 2016, and had cerebrospinal fluid (CSF) collected for routine diagnostic testing. Demographic and clinical data were abstracted from medical charts, and residual specimens were sent to CDC for confirmatory testing and typing. RESULTS: Of 472 eligible case-patients, CSF specimen was available for 319 (67.6%). Among those, 13 (4.1%) were positive for EV and 11 (3.4%) for PeV. Most case-patients (86.8%, n = 277) were aged <2 months, as were all EV- or PeV-positive case-patients. None of the positive case-patients had underlying conditions, and the chief complaint for 91.7% (n = 22) was fever. Twelve positive case-patients were admitted to intensive care (ICU) and had brief hospital stays (median 2 days). Sequencing revealed a variety of EV types and the predominance of PeV-A3 among the PeV-positive case-patients. CONCLUSIONS: A range of EV and PeV types were associated with acute febrile illnesses leading to hospitalization in children aged <2 months. Approximately half of EV and PeV case-patients were admitted to ICU, but length of hospital stay was brief and illnesses were generally self-limiting. Clinicians should consider EV and PeV infections in infants presenting with febrile illness.
has issue date
2019-04-25
(
xsd:dateTime
)
bibo:doi
10.1016/j.jcv.2019.04.005
bibo:pmid
31100674
has license
no-cc
sha1sum (hex)
0177ecbf4b0c05010c4830a95a8913b3b5d2e87c
schema:url
https://doi.org/10.1016/j.jcv.2019.04.005
resource representing a document's title
Picornavirus etiology of acute infections among hospitalized infants()
has PubMed Central identifier
PMC7172211
has PubMed identifier
31100674
schema:publication
J Clin Virol
resource representing a document's body
covid:0177ecbf4b0c05010c4830a95a8913b3b5d2e87c#body_text
is
schema:about
of
named entity 'viral'
named entity 'positive'
named entity 'self-limiting'
named entity 'Methods'
named entity 'infections'
named entity 'Results'
named entity 'length'
named entity 'infections'
named entity 'etiology'
named entity 'Picornavirus'
named entity 'BUT'
named entity '283'
named entity 'Demographic'
named entity 'positive'
named entity 'infections'
named entity 'specimen'
named entity 'etiologies'
named entity 'fever'
named entity 'aged'
named entity 'PeV'
named entity 'febrile'
named entity 'febrile'
named entity 'PeV'
named entity 'PeV'
named entity 'acute illness'
named entity 'viruses'
named entity 'intensive care'
named entity 'chief complaint'
named entity 'PeV'
named entity 'Demographic'
named entity 'ICU'
named entity 'PeV'
named entity 'public health'
named entity 'white blood cell count'
named entity 'PeV'
named entity 'Emerging Infections'
named entity 'PeV'
named entity 'CDC'
named entity 'PeV'
named entity 'self-limiting'
named entity 'cellulitis'
named entity 'Morbidity and mortality'
named entity 'PeV'
named entity 'fever'
named entity 'diagnostic evaluation'
named entity 'PeV'
named entity 'California'
named entity 'PeV'
named entity 'febrile illness'
named entity 'PeV'
named entity 'CSF'
named entity 'CDC'
named entity 'PeV'
named entity 'viruses'
named entity 'rhabdoviruses'
named entity 'red blood cell'
named entity 'PeV'
named entity 'PeV'
named entity 'lumbar puncture'
named entity 'PeV'
named entity 'Colorado'
named entity 'Colorado'
named entity 'PeV'
named entity 'serum'
named entity 'Respiratory Diseases'
named entity 'PeV'
named entity 'freeze-thaw'
named entity 'acyclovir'
named entity 'clinical diagnostic'
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