About: Key Vitamin D Target Genes with Functions in the Immune System

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About: Key Vitamin D Target Genes with Functions in the Immune System Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Key Vitamin D Target Genes with Functions in the Immune System
Creator	Carlberg, Carsten Hanel, Andrea Koivisto, Oona
Source	Medline; PMC
abstract	The biologically active form of vitamin D(3), 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), modulates innate and adaptive immunity via genes regulated by the transcription factor vitamin D receptor (VDR). In order to identify the key vitamin D target genes involved in these processes, transcriptome-wide datasets were compared, which were obtained from a human monocytic cell line (THP-1) and peripheral blood mononuclear cells (PBMCs) treated in vitro by 1,25(OH)(2)D(3), filtered using different approaches, as well as from PBMCs of individuals supplemented with a vitamin D(3) bolus. The led to the genes ACVRL1, CAMP, CD14, CD93, CEBPB, FN1, MAPK13, NINJ1, LILRB4, LRRC25, SEMA6B, SRGN, THBD, THEMIS2 and TREM1. Public epigenome- and transcriptome-wide data from THP-1 cells were used to characterize these genes based on the level of their VDR-driven enhancers as well as the level of the dynamics of their mRNA production. Both types of datasets allowed the categorization of the vitamin D target genes into three groups according to their role in (i) acute response to infection, (ii) infection in general and (iii) autoimmunity. In conclusion, 15 genes were identified as major mediators of the action of vitamin D in innate and adaptive immunity and their individual functions are explained based on different gene regulatory scenarios.
has issue date	2020-04-19(xsd:dateTime)
bibo:doi	10.3390/nu12041140
bibo:pmid	32325790
has license	cc-by
sha1sum (hex)	009ca0b426fb4396f2098898bcd4c1a0877582c8
schema:url	https://doi.org/10.3390/nu12041140
resource representing a document's title	Key Vitamin D Target Genes with Functions in the Immune System
has PubMed Central identifier	PMC7230898
has PubMed identifier	32325790
schema:publication	Nutrients
resource representing a document's body	covid:009ca0b426fb4396f2098898bcd4c1a0877582c8#body_text
is schema:about of	named entity 'level' named entity 'CAMP' named entity 'compared' named entity 'Target' named entity 'USED' named entity 'TO IDENTIFY' named entity 'TREM1' named entity 'FORM' named entity 'TREATED' named entity 'SCENARIOS' named entity 'TRANSCRIPTOME' named entity 'THBD' named entity 'PRODUCTION' named entity 'SEMA6B' named entity 'LED' named entity 'CD14' named entity 'ROLE' named entity 'APPROACHES' covid:arg/009ca0b426fb4396f2098898bcd4c1a0877582c8 named entity 'based' named entity 'identified' named entity 'transcription factors' named entity 'VDR' named entity 'FN1' named entity 'RNA-seq' named entity 'vitamin' named entity 'inflammation' named entity 'CEBPB' named entity 'bactericidal' named entity '1,25(OH)2D3' named entity 'epigenome' named entity 'Venn diagrams' named entity 'innate immunity' named entity 'peptide' named entity 'vitamin' named entity 'EtOH' named entity 'enhancers' named entity 'TSS' named entity 'molecule' named entity 'chromatin' named entity 'ligand' named entity 'group 1' named entity 'vitamin' named entity 'protein' named entity 'endothelium' named entity 'TSS' named entity 'VDR' named entity 'FN1' named entity 'basal' named entity 'inflammation' named entity 'CD93' named entity 'CD93' named entity 'THBD' named entity 'dynamic response' named entity 'TREM1' named entity 'MAPK13' named entity 'TLR4' named entity 'H3K27ac' named entity 'THP-1' named entity 'FN1' named entity 'TSS' named entity 'VDR' named entity 'RNA-seq' named entity 'gene expression' named entity 'group 1' named entity 'pattern recognition receptors' named entity 'VDR' named entity 'hydroxylation' named entity 'CD93' named entity 'monocytes' named entity 'solvent' named entity 'chromatin' named entity 'VDR' named entity 'histone' named entity 'p-value' named entity 'FAIRE-seq' named entity 'TREM1' named entity 'CD93' named entity 'formaldehyde'

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