About: Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques

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About: Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques
Creator	Deng, Yong-Qiang Qin, Cheng-Feng Zhang, Bo Shi, Pei-Yong Jiang, Tao Fink, Katja Poidinger, Michael Dong, Hongping Balakrishnan, Thavamalar Li, Shi-Hua Li, Xiao-Feng Toh, Ying-Xiu Zolezzi, Francesca Chang, David Ellis, Brett Ellis, Esther Zü St, Roland
Source	Medline; PMC
abstract	Dengue virus is transmitted by Aedes mosquitoes and infects at least 100 million people every year. Progressive urbanization in Asia and South-Central America and the geographic expansion of Aedes mosquito habitats have accelerated the global spread of dengue, resulting in a continuously increasing number of cases. A cost-effective, safe vaccine conferring protection with ideally a single injection could stop dengue transmission. Current vaccine candidates require several booster injections or do not provide protection against all four serotypes. Here we demonstrate that dengue virus mutants lacking 2′-O-methyltransferase activity are highly sensitive to type I IFN inhibition. The mutant viruses are attenuated in mice and rhesus monkeys and elicit a strong adaptive immune response. Monkeys immunized with a single dose of 2′-O-methyltransferase mutant virus showed 100% sero-conversion even when a dose as low as 1,000 plaque forming units was administrated. Animals were fully protected against a homologous challenge. Furthermore, mosquitoes feeding on blood containing the mutant virus were not infected, whereas those feeding on blood containing wild-type virus were infected and thus able to transmit it. These results show the potential of 2′-O-methyltransferase mutant virus as a safe, rationally designed dengue vaccine that restrains itself due to the increased susceptibility to the host's innate immune response.
has issue date	2013-08-01(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1003521
bibo:pmid	23935499
has license	cc-by
sha1sum (hex)	0080d3bd9fb92e022c27715c2d1249042aa998b8
schema:url	https://doi.org/10.1371/journal.ppat.1003521
resource representing a document's title	Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques
has PubMed Central identifier	PMC3731252
has PubMed identifier	23935499
schema:publication	PLoS Pathog
resource representing a document's body	covid:0080d3bd9fb92e022c27715c2d1249042aa998b8#body_text
is schema:about of	named entity 'O-METHYLTRANSFERASE ACTIVITY' named entity 'STOP' covid:arg/0080d3bd9fb92e022c27715c2d1249042aa998b8 named entity 'COST' named entity 'ELICIT' named entity 'WILD-TYPE' named entity 'MACAQUES' named entity 'ATTENUATED' named entity 'IMMUNOGENIC' named entity 'HIGHLY' named entity 'IFN' named entity 'PROVIDE' named entity 'DENGUE TRANSMISSION' named entity 'FEEDING' named entity 'CONVERSION' named entity 'HAVE' named entity 'EVERY YEAR' named entity 'URBANIZATION' named entity 'MOSQUITOES' named entity 'CASES' named entity 'ATTENUATED' named entity 'SOUTH' named entity 'HABITATS' named entity 'DO NOT' named entity 'ANIMALS' named entity 'THESE' named entity 'TYPE VIRUS' named entity 'PEOPLE' named entity 'STRONG' named entity 'SINGLE' named entity 'VIRUSES' named entity 'MICE' named entity 'VACCINE' named entity 'TO TRANSMIT' named entity 'ADAPTIVE IMMUNE RESPONSE' named entity 'INNATE IMMUNE RESPONSE' named entity 'RESULTING IN' named entity 'LIVE' named entity 'O-METHYLTRANSFERASE' named entity 'DESIGN' named entity 'MUTANTS' named entity 'EXPANSION' named entity 'LACKING' named entity 'INJECTION' named entity 'TRANSMITTED BY' named entity 'PROGRESSIVE' named entity '27S' named entity 'ASIA' named entity 'INCREASED SUSCEPTIBILITY' named entity 'BOOSTER' named entity 'CENTRAL AMERICA' named entity 'HERE' named entity 'CHALLENGE' named entity 'SPREAD' named entity '100%' named entity 'BLOOD' named entity 'AEDES' named entity 'DUE TO' named entity 'EFFECTIVE' named entity 'MICE' named entity 'PLAQUE FORMING UNITS' named entity 'IMMUNIZED' named entity 'HOST' named entity 'MUTANTS' named entity 'INCREASING'

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