About: Changes in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic study

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About: Changes in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Changes in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic study
Creator	Eckersall, David Escribano, Damián Franco-Martínez, Lorena Guillemin, Nicolas Horvatić, Anita Kocatürk, Meriç Lamy, Elsa Martínez-Subiela, Silvia Mrljak, Vladimir Tvarijonaviciute, Asta Yilmaz, Zeki Cerón, José
Source	Elsevier; Medline; PMC
abstract	Abstract The present study evaluated the changes in salivary proteome in parvoviral enteritis (PVE) in dogs through a high-throughput quantitative proteomic analysis. Saliva samples from healthy dogs and dogs with severe parvovirosis that survived or perished due to the disease were analysed and compared by Tandem Mass Tags (TMT) analysis. Proteomic analysis quantified 1516 peptides, and 287 (corresponding to 190 proteins) showed significantly different abundances between studied groups. Ten proteins were observed to change significantly between dogs that survived or perished due to PVE. Bioinformatics’ analysis revealed that saliva reflects the involvement of different pathways in PVE such as catalytic activity and binding, and indicates antimicrobial humoral response as a pathway with a major role in the development of the disease. These results indicate that saliva proteins reflect physiopathological changes that occur in PVE and could be a potential source of biomarkers for this disease.
has issue date	2018-10-31(xsd:dateTime)
bibo:doi	10.1016/j.cimid.2018.09.011
bibo:pmid	30396423
has license	els-covid
sha1sum (hex)	001ec025dd65db8a47827c8f49d9c41d60f35d00
schema:url	https://doi.org/10.1016/j.cimid.2018.09.011
resource representing a document's title	Changes in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic study
has PubMed Central identifier	PMC7124818
has PubMed identifier	30396423
schema:publication	Comparative Immunology, Microbiology and Infectious Diseases
resource representing a document's body	covid:001ec025dd65db8a47827c8f49d9c41d60f35d00#body_text
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